Colts vs. Broncos Week 2 Final Score Predictions: Indy looks to get revenge for their embarrassing loss last season 

Broncos 32 - Colts 21

The Denver Broncos and Indianapolis Colts met during the 2024 campaign with a game that ultimately allowed Denver into the postseason. While Denver looked sluggish on offense, their defense was in midseason form throughout its Week 1 victory against the Tennessee Titans. Denver's defensive front, paired with Patrick Surtain locking down the No. 1 receiver in Calvin Ridley, made life difficult for the Titans, and I expect the same against the Colts. Denver led the league in sacks in 2024 and may very well repeat in 2025 with the performances seen in Week 1.

The team is still without Dre Greenlaw, but John Franklin-Meyers, Nate Adkins, and Alex Singleton are trending in the right direction for the contest. Both Denver and Indianapolis enter the matchup undefeated, but I have Denver winning this game with the offense getting back on track and the emergence of RJ Harvey in the backfield. Harvey will find the endzone for the first time in his NFL career, and Nix will finish with a complete, turnover-free performance. - Adam Zientek, Buffalo Bills & Denver Broncos beat writer

Colts 20 - Broncos 17

If you had asked me my prediction for this game before Week 1, I would have had a very different response. I didn't know what to expect from a Daniel Jones-led Colts offense, but their season opener was pretty eye-opening. The Broncos defense isn't the Dolphins defense, though, so I don't expect to see another 30+ scoring day. But watching Bo Nix and their offense struggle against a Titans defense I believe to be significantly worse than the Colts' tells me they don't need to put up those types of numbers in Week 2.

If Jones can operate the offense similarly to what we saw in Week 1 against arguably the best defense in the NFL, the Broncos, people will have no choice but to take them seriously going forward. I think the Broncos defense will force more mistakes, and we will surely see punter Rigoberto Sanchez get his first offical punt in the stat books. However, I think Lou Anarumo will force Nix into mistakes, and I think we will see him have an even worse performance than the season opener. Even without star CB Charvarius Ward, I'm going to bet on Anarumo's unit to help seal a win that I expect to come down to the wire. - Destin Adams, Indianapolis Colts beat writer