Watch: Bills RB James Cook breaks off 49-yard TD run, notching third first-half score

The miraculous run was Cook's second rushing touchdown of the game, scoring from one yard out with 6:25 left in the second quarter. The 24-year-old has recorded two rushing scores in each of his first two seasons in the league, meaning he's already matched his single-season career high through just two quarters.

Cook's first score came just 5:11 into the game, giving the Dolphins a 7-0 lead early. Following a Tua Tagovailoa interception, the Bills running back got involved in the passing game, hauling in a 17-yard touchdown pass from quarterback Josh Allen on fourth down to kick off the scoring.

The Bills took a 24-10 lead over the Dolphins into halftime, unsurprisingly led by Cook's incredible efforts. At the break, he had 60 rushing yards (five carries), averaging 12.0 per carry with two touchdowns, along with one catch for 17 yards and a score.