Venus Williams is the biggest big name to withdraw from the U.S. Open. Peter Van den Berg-USA TODAY Sports

Venus Williams out of U.S. Open with lingering leg injury

The upcoming U.S. Open has lost yet another big name. 

Less than 12 hours after Serena Williams withdrew from the year's final Grand Slam, Venus Williams joined her sister and men's superstars Roger Federer and Rafael Nadal by pulling out of the major tournament held in New York City because of a lingering leg injury: 

"I tried my best here in Chicago [at the WTA 250 Chicago Women's Open], but I just was unable to figure out the equation." Venus Williams explained, per the WTA website. "And there's been so many times where I've been able to figure it out, even not in the best of my health, but this time, I just couldn't make any miracles work." 

The 41-year-old continued that the U.S. Open is her "favorite" of the Grand Slam competitions. 

Williams won the 2000 U.S. Open and successfully defended her title the following year but hasn't hoisted that trophy since. She has seven major titles on her career resume and had received a wild-card berth into this year's U.S. Open. 

The tournament's main draw begins this Monday and runs through Sept. 12. 

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