Colorado's odds of winning championship change after Week 4 loss

Following Saturday's loss in Eugene, DraftKings now lists Colorado as a  250-1 longshot to win this year's CFB championship. There is no word yet on whether or not the Buffs are still the most bet-on team in college football, although major outlets are already looking elsewhere as ESPN didn't even list them in their power rankings following the loss at Autzen Stadium. 

Shedeur Sanders and company have a chance to get back into the win column and improve their odds, although that will be difficult in Week 5 against No. 8 USC. The 3-0 Trojans are coming off of a haphazard 42-28 win against Arizona State, although they were still propelled by Heisman Trophy winner Caleb Williams, who recorded 322 yards and three TDs with an additional two rushing scores. USC's defense isn't as stealthy as Oregon's, so Sanders could have a slightly easier time under center in Week 5, but the Trojans will still be hard to beat.

Speaking of which, USC is currently listed at 16-1 odds at DK to win the national college football championship game. They are also the 22-point favorites to win Saturday's game.