Watch: E. Kentucky vs. Louisville Full Game Replay | 2025 ACC Football

In Louisville, the Cardinals handled their business with a convincing 51-17 win at home over Eastern Kentucky to start off the 2025 season. Miller Moss got the start for the Cards and finished the game with 231 total yards on 17-25 passing with a passing touchdown and a rushing touchdown in the win. Isaac Brown rushed for 126 yards and 2 touchdowns on just 6 carries while Duke Watson had a touchdown catch. Brady Allen played the 2nd half for the Cards and completed 6-9 passes for 69 yards including a 31-yard touchdown pass to Kris Hughes. The Louisville defense was truly stingy, giving up just 150 total yards while Clev Lubin registered 2 of the team's 4 sacks.