Yardbarker
x
Preview: Louisville Cardinals vs. Clemson Tigers
Nov 8, 2025; Louisville, Kentucky, USA; Louisville Cardinals running back Keyjuan Brown (22) runs the ball against the California Golden Bears during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images Jamie Rhodes-Imagn Images

After suffering a heartbreaking loss this past weekend, the Louisville football program doesn't have much time to refocus, hosting Clemson on a short turnaround for a primetime weeknight matchup.

Louisville could not make winning plays when they absolutely had to in their last matchup, eventually falling 29-26 in overtime to Cal to see their ACC and College Football Playoff hopes all but evaporate. QB Miller Moss went just 20-of-38 for 203 yards, and the Cardinals as a whole put up just 351 yards offense, while also giving up a season-worst 427 yards to the Golden Bears.

As for the Tigers, it has been far from the season that they envisioned having. Despite started the season as the No. 4 team in the the sport and being the preseason pick to win the ACC, Clemson opened up the season at 1-3, and head into their matchup with UofL at just 4-5. That being said, they were able to secure a win in their last time out, coming out with a 24-10 victory over Florida State

This will be the 10th all-time meeting between the two programs, with the Tigers holding an 8-1 edge. In the last matchup, the Cardinals finally got in the win column in the series, capturing a 33-21 victory in Death Valley back on Nov. 2, 2024.

Clemson Tigers (4-5, 3-4 ACC) at No. 19 Louisville Cardinals (7-2, 4-2 ACC)

  • Date/Time: Friday, Nov. 14 at 7:30 p.m. EST
  • Place: L&N Stadium in Louisville, Ky.
  • TV: ESPN - xxx (play-by-play), xxx (analyst) and xxx (sideline).
  • Channel (Louisville)/Live Stream: Spectrum: 31; Dish: 140; DirecTV: 206.
  • Radio (Louisville): 93.9 FM - Paul Rogers (play-by-play), Craig Swabek (analyst) and Jody Demling (sideline).

This article first appeared on Louisville Cardinals on SI and was syndicated with permission.

More must-reads:

Customize Your Newsletter

Yardbarker +

Get the latest news and rumors, customized to your favorite sports and teams. Emailed daily. Always free!