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Top MLB DFS Start‘em/Sit‘em For September 21st
- May 19, 2025; Pittsburgh, Pennsylvania, USA; Cincinnati Reds shortstop Elly De La Cruz (44) runs the bases on his way to scoring a run against the Pittsburgh Pirates during the first inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

With the MLB last weekend here, fantasy players could win cash prizes to end the weekend with a bang in today’s top MLB DFS lineups and stacks. Sunday’s 15-game slate will keep the weekend going with a bang, with the season winding down to a week left. With the postseason getting close for the MLB season, fantasy players could win cash prizes in today’s top MLB DFS lineups and fantasy stacks this Sunday.

Sunday’s games will end the weekend going with a bang, with the New York Mets ending their homestand of the season against the Washington Nationals.  Another game that could help players win cash prizes for tonight’s weekend slate of games is the Chicago Cubs’ final game of their road trip in Cincinnati against the Reds, which will conclude their four-game series. 

The MLB season’s last week is tomorrow, and fantasy players could win cash prizes to end the weekend with a bang for today’s top MLB DFS lineups and fantasy stacks.

September 21st Top MLB DFS Lineup Starters 

3B Ryan McMahon, New York Yankees at Baltimore Orioles ($3,400 – DraftKings/2,800-Fanduel)

To start Sunday afternoon’s top MLB DFS lineups, Ryan McMahon of the New York Yankees should be in your lineups. In the win against the Orioles, McMahon went 0-4 with a strikeout in the blowout win. 

McMahon has been sluggish for the Yankees this season, but could have a bounce-back game against the Orioles today. Fantasy players could see a multi-RBI game from the Yankees veteran infielder against the Orioles today. 

1B Kyle Manzardo, Cleveland Guardians at Minnesota Twins ($4,500 – DraftKings/2,900-Fanduel)

Kyle Manzardo of the Cleveland Guardians should be in Sunday afternoon’s top MLB DFS lineups for fantasy players. In the win against the Twins, Manzardo went 1-5 with a run, an RBI, and a strikeout

Manzardo has been having a strong second half with Cleveland, having a strong winning streak this September. DFS players could see a multi-RBI game from the Guardians’ emerging slugging first baseman against the Twins to end the weekend. 

2B Brice Turang, Milwaukee Brewers at St. Louis Cardinals ($4,600 – DraftKings/3,500-Fanduel)

The last player to have for your fantasy lineups is Brice Turang, of the Milwaukee Brewers, in this afternoon’s top MLB DFS lineups. During a win against the Cardinals, Turang went 1-5 with an RBI and two strikeouts. 

Turang is having a breakout season for the Brewers, and fantasy players could win cash prizes with the Brewers’ emerging star. Fantasy players could see a multi-home run game from Turang to help players win cash prizes. 

September 21st Top MLB DFS Benchwarmers 

OF Riley Greene, Atlanta Braves at Detroit Tigers ($4,700 – DraftKings/3,500-Fanduel) 

Riley Greene is the first player who should be on your top MLB DFS fantasy benches for Sunday afternoon’s games. In the loss against the Braves, Greene went 0-4 with two strikeouts in the crushing loss. 

Greene and the Tigers have been struggling with their five-game losing streak and collapsing this September. With the Tigers collapsing, fantasy players could see Greene have another hitless game for today’s top MLB DFS fantasy lineups. 

OF Brandon Nimmo, Washington Nationals at New York Mets ($4,200 – DraftKings/3,000-Fanduel)

Brandon Nimmo of the New York Mets is another player who should be on your fantasy bench in this afternoon’s Top MLB DFS lineups. In the Mets’ brutal loss to the Nationals, Nimmo went 0-5 with a run in the extra-innings loss. 

Nimmo has been struggling, and last night he had terrible at-bats that cost the Mets and fantasy players cash prizes. Fantasy players could see another hitless game from the Mets veteran star. 

SS Gunnar Henderson, New York Yankees at Baltimore Orioles ($4,600 – DraftKings/3,400-Fanduel) 

Gunnar Henderson of the Baltimore Orioles should be the last player on your top MLB DFS bench for Sunday afternoon’s games. In a brutal loss to the Yankees, Henderson went 1-4 with a stolen base. 

Henderson has been underachieving this season and could have another poor game for fantasy lineups. DFS players could see a multi-strikeout game from the Orioles superstar to end the weekend after a long and dreadful season for Baltimore.

Total Apex Media Stack Of The Day

Cincinnati Reds right fielder Jake Fraley (27) crosses the plate on a two-run home run in the fourth inning of the MLB National League game between the Cincinnati Reds and the Los Angeles Dodgers at Great American Ball Park in downtown Cincinnati on Tuesday, July 29, 2025. The Reds led 3-2 after four innings.

Sunday’s top MLB DFS stack should be the Cincinnati Reds, Elly De La Cruz, Matt McLain, and TJ Friedl. The Reds are heating up to end the weekend, and fantasy players could win cash prizes to end this weekend with a bang. Fantasy players could win big with the Reds lineup to win cash prizes in today’s top MLB DFS lineup stacks. 

The first player for today’s top MLB DFS stack is De La Cruz against a weak Cubs pitching staff to end the weekend. In the win against the Cubs, Cruz went 1-3 with a strikeout during the close victory against their division rivals. Cruz has been heating up for the Reds, and could have a great game to end the weekend for fantasy players. DFS players could see a multi-RBI game from the Reds’ emerging superstar against the Cubs to end the weekend for fantasy lineups.

Another player, who could have a great game for fantasy stacks today, is McLain, who could have a strong performance against the Cubs. In the win against the Cubs, McLain went 1-4 with a strikeout and a run. McLain has been sluggish this season, but could have a great game against the Cubs to win cash prizes. DFS players could see a multi-hit game from the Reds’ star infielder and potentially a home run to win cash prizes. 

The last player, who could have a great game for fantasy lineups, is Friedl, who has been hitting the ball this season. During the series win against the Cubs, Friedl went 2-4 with a home run and a strikeout. Friedl has been having a solid season for the Reds, and could have a strong game to end the weekend for fantasy lineups. DFS players could see a home run from the Reds veteran outfielder to end the weekend for fantasy players. With the weekend ending, fantasy players could win cash prizes in today’s top MLB DFS lineups and fantasy stacks. 

This article first appeared on Total Apex Fantasy Sports and was syndicated with permission.

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