49ers Announce Decision on All-Pro After Win Over Rams

In Week 6, the 49ers will look for their second straight win, hitting the road to face Baker Mayfield and the Buccaneers. However, despite McCaffrey being a full participant in practice leading up to the Rams game, San Francisco elected to rest the four-time All-Pro for Wednesday's practice session.

This is likely just a precautionary measure from the 49ers, especially after McCaffrey has dealt with injuries over the past couple of seasons. He was even forced to miss most of training camp with a calf injury. But, outside of Week 5, San Francisco has elected to rest the running back in each Wednesday practice session.

Along with McCaffrey, left tackle Trent Williams also sat out of practice due to rest.

But it seems likely the rest day for McCaffrey is nothing to fear for 49ers fans, as the former Stanford Cardinal star opened up about facing Buccaneers linebacker Lavonte Davis once again.

"I'm sick of him, man," McCaffrey said. "I'm sick of him. Nah, he's a hell of a player. Always brings a big challenge and just somebody that has always played the game the right way. And to my opinion, doesn't get enough credit. Once again, just their whole defense and guys like him, when you have a veteran like that, they spark a lot of challenges that you got to be ready for."