49ers vs. Seahawks: First injury report of the 2025 NFL season

The San Francisco 49ers released their first injury report of the 2025 NFL season ahead of Sunday's Week 1 matchup against the Seattle Seahawks at Lumen Field. Coaches and players are determined to rebound from last season's disappointing 6-11 finish.

Wide receiver Jauan Jennings returned to practice on Monday and participated again on Wednesday, though he remains limited in his first week back. Head coach Kyle Shanahan said he expects Jennings to play this weekend.

Guard Dominick Puni also rejoined practice Monday after recovering from a PCL sprain suffered in the 49ers' second preseason game. Like Jennings, he was limited on Wednesday.

Defensive end Yetur Gross-Matos and rookie wide receiver Jordan Watkins were the only active-roster players who did not practice due to injuries.

Minor roster move: The 49ers waived Tanner Mordecai after reaching an injury settlement. The quarterback reverted to San Francisco's injured reserve list after clearing waivers last week.

Below are Wednesday's practice participation reports for both the 49ers and Seahawks, which were provided by the 49ers Communications staff. It's worth noting that the 49ers' report is an estimate, as practice was not yet complete when it was released.

San Francisco 49ers Wednesday Practice

Did Not Participate In Practice
DE Yetur Gross-Matos (knee), WR Jordan Watkins (ankle), T Trent Williams (not injury related - resting player)

Limited Participation in Practice
RB Jordan James (finger), WR Jauan Jennings (calf), G Dominick Puni (knee)

Full Participation in Practice
G Ben Bartch (elbow), DT Kalia Davis (groin), RB Isaac Guerendo (shoulder), DE Bryce Huff (ankle), QB Mac Jones (knee), DE Sam Okuayinonu (shoulder), S Jason Pinnock (heel), CB Upton Stout (calf), DT C.J. West (knee), DE Mykel Williams (knee)

Seattle Seahawks Wednesday Practice

Limited Participation in Practice
WR Jake Bobo (concussion), LB Uchenna Nwosu (knee), WR Cody White (shoulder), WR Dareke Young (hamstring)

Full Participation in Practice
WR Tory Horton (ankle)