Sep 21, 2025; Nashville, Tennessee, USA; Indianapolis Colts cornerback Kenny Moore II (23) intercepts a pass for a pick six during the first quarter at Nissan Stadium. Mandatory Credit: Steve Roberts-Imagn Images Steve Roberts-Imagn Images

Colts' Kenny Moore II to Miss Multiple Weeks

Originally posted on Indianapolis Colts on SI
By Drake Wally | Last updated Sep 22, 2025 12:38 PM ET

The Indianapolis Colts (3-0) continued their fantastic start to the 2025 NFL season by defeating the AFC South rival Tennessee Titans (0-3) by 21 points (41-20).

While the victory is a triumph, a few notable injuries stand out for Indy. First, wide receiver Alec Pierce fell hard on a deep throw from Daniel Jones. He ended up leaving the game to be evaluated for a concussion.

Second, cornerback Kenny Moore II went down with a calf injury late in the game. Now, it's official that Moore will miss a couple of weeks with the injury. This prompted the Colts to sign veteran cornerback Mike Hilton for depth.

#Colts Pro Bowl DB Kenny Moore II suffered a calf injury in Sunday's win, and he's expected to miss a couple of weeks, source says. Not a major injury.

For depth, the team is signing veteran CB Mike Hilton to their practice squad.
— Ian Rapoport (@RapSheet) September 22, 2025

Moore was having a fantastic day, logging two tackles, a pass breakup, and a critical pick-six of Titans quarterback Cam Ward early in the contest.

This gave Indianapolis a huge amount of momentum, effectively changing how the Titans had to approach the game from the first quarter and on.

Kenny Moore’s pick-six was the earliest defensive touchdown in franchise history.

It also moved him into a tie for second among active players with four career pick-sixes. pic.twitter.com/ZIdgLZn8B8
— SleeperColts (@SleeperColts) September 21, 2025

Moore is one of the best defensive players on the roster and a critical part of Lou Anarumo's scheme. With him missing time, adjustments will need to be made with the Los Angeles Rams hosting Indianapolis next week at SoFi Stadium.

Moore was having another good season before going down with the calf injury, posting ten tackles (one for loss), a fumble forced, a sack, two pass breakups, and an interception return for touchdown.

Moore isn't just one of the best defensive players for the Colts, but also can be the best nickel cornerback in the NFL on any given gameday. Yesterday against the Titans, he showed that caliber of performance.

Moore's Pro Football Focus defensive grades also display how well he's played in his ninth NFL season. Moore has an overall mark of 80.8, a run-stopping grade of 70.5, and a coverage grade of 79.1.

With this injury, it might signify that the rookie Johnathan Edwards will start while Moore rests up, or that the new signing, Hilton, will immediately get playing time. Also, Chris Lammons is on the practice squad and could get called up to the active roster.

Anarumo will have to pivot perfectly to combat Sean McVay's offense and quarterback Matt Stafford next Sunday. Moore's absence will be felt due to how good he his, and replacing a player of his level is nearly impossible to do on the fly.

Indy's cornerback room has been plagued with injuries this year, and none compare to the weight of Moore's.