Indianapolis Colts at San Francisco 49ers Week 7 betting preview

The Indianapolis Colts (2-4) face the San Francisco 49ers (2-3) at Levi's Stadium on Sunday for Week 7 of the NFL. The 49ers started the week as 4.0-point favorites but the spread has since moved to 4.5. The total points line is set at 44.0.

• The Colts have a 4-2-0 ATS record this season, while the 49ers hold a record of 1-4-0.
• The Colts have a 3-3-0 O/U record this season (meaning three games have gone over the total points line and three have gone under). The 49ers have a 2-3-0 O/U record.

Points on the board                

• The Colts are averaging 23.2 points per game this season (19th in the league). Comparatively, the 49ers are averaging 23.4 (17th).
• Defensively, the Colts are giving up 21.8 points per game this season (11th in the league), while the 49ers are giving up an average of 23.8 points (15th).

Moving the chains                

• With an average of 367.5, the Colts rank 15th in the league for total yards per game. Comparatively, the 49ers rank 14th with 368.2 yards per game.
• In terms of yards allowed, the Colts are giving up 366.5 per game this season (20th in the league), an inferior number to the 49ers, who are giving up an average of 329.8 (6th).

Ascendency in the air?                

• The Colts have recorded 243.3 passing yards per game this season (16th in the league). Comparatively, the 49ers' defense has given up 216.6 passing yards per game (7th).
• Meanwhile, the 49ers have recorded 246.2 passing yards per game this season (14th in the league), while the Colts' defense has given up 255.5 passing yards per game (20th).

Advantage on the ground?              

• Looking at the ground game, the Colts have recorded 124.2 rushing yards per game this season (11th in the league). The 49ers rank slightly worse when defending the run, sitting 18th while allowing 113.2 per game.
• On the other hand, the 49ers have recorded 122.0 rushing yards per game this season (12th in the league). The Colts have performed at a similar level when defending the run, conceding 111.0 per game (14th).

Protecting the ball                

• Looking at their ability to force turnovers, the Colts have recorded 12 total takeaways this season (4th in the league), while the 49ers have failed to perform at the same level, recording 2 (T31st).
• On offense, the Colts have recorded 5 total giveaways this season (T3rd in the league), bettering the 49ers' number of 7 (T14th).

First to Score               

The Colts are +115 to score first, while the 49ers are -145.

• The Colts have scored first in three of their six games this season.
• The 49ers have scored first in two of their five games this season.

Which team will score the first touchdown?              

• The Colts have recorded the first touchdown in three of their six games this season.
• The 49ers have recorded the first touchdown in three of their five games.

First Scoring Play              

• Indianapolis Touchdown 2 / 6 +320
• Indianapolis Field Goal 1 / 6 +330
• Indianapolis Safety 0 / 6 +5000
• San Francisco Touchdown 2 / 5 +175
• San Francisco Field Goal 0 / 5 +300
• San Francisco Safety 0 / 5 +5500

Which team will get a quick start?               

The Colts are +150 to be the first team to reach 10 points, while the 49ers are -177.

• The Colts have been the first to score 10 points in three of their six games this season.
• The 49ers have been the first to score 10 points in two of their five games this season.

First Quarter Moneyline                

• The 49ers are favored in the 1st Quarter Moneyline market, currently at -159, while the Colts are +140.
• The Colts have a 2-4-0 first quarter W/L/T record this season, while the 49ers hold a record of 2-3-0.

Last Time They Met              

The Colts recorded a 26-23 overtime victory over the 49ers at Lucas Oil Stadium when these teams last met in Week 5, 2017.