Cary Edmondson-Imagn Images

Nick Bosa out for season with torn ACL

Originally posted on Larry Brown Sports | By Larry Brown | Last updated Sep 22, 2025 3:03 PM ET

Nick Bosa’s injury is a serious one.

The San Francisco 49ers defensive end is out for the season after suffering a torn ACL on Sunday. Bosa went down with the knee injury late in the first quarter of his team’s 16-15 win over the Arizona Cardinals.

Bosa gave a thumbs down sign as he was walking along the sidelines, indicating he knew the injury was a bad one.

Nick Bosa signaled a to someone in the crowd after he was shaken up with a possible injury. pic.twitter.com/82bo7OeDZL
— Alex Tran (@nineralex) September 21, 2025

This is the second time in his career that Bosa has suffered a torn ACL. He got hurt in Week 2 of the 2020 season, which caused him to miss most of the year.

Bosa had two tackles in the game prior to suffering his injury. He finishes the season with 17 tackles and 2 sacks in his three games.

Bosa, who turns 28 in October, made the Pro Bowl in 2021, the year after he tore his ACL. He won Defensive Player of the Year in 2022. 49ers fans are hoping that Bosa will be able to come back as effectively next season.

This article first appeared on Larry Brown Sports and was syndicated with permission.

More must-reads: