Inter need a victory over Real Sociedad to win the Champions League group, but Lautaro Martinez is initially rested for Alexis Sanchez, while Davide Frattesi and Juan Cuadrado also start.
It kicks off at San Siro at 20.00 GMT.
These sides drew 1-1 in Spain back in September and are currently locked together on 11 points, having already qualified for the Round of 16.
If this too is a stalemate, then their head-to-head record will be identical, but Real Sociedad have a better overall goal difference and would therefore be top seeds in the draw.
Simone Inzaghi is top of Serie A, but missing injured defenders Stefan de Vrij, Benjamin Pavard and Denzel Dumfries.
Lautaro Martinez is initially rested in favour of Alexis Sanchez with Marcus Thuram, while Carlos Augusto again fills in with Matteo Darmian in defence, as Alessandro Bastoni only made his comeback at the weekend.
Frattesi gets a rare opportunity in place of Nicolò Barella and it’s the first Inter start for Cuadrado too.
Henrikh Mkhitaryan and Kristjan Asllani need to be careful, as they are one yellow card away from suspension.
Real Sociedad lost Brais Mendez to a fractured arm at the weekend, joining Martin Merquelanz, Ander Barrenetxea and Mohamed-Ali Cho on the treatment table.
Former Milan striker Andre Silva is on the bench, as ex-Roma forward Umar Sadiq is preferred upfront with Japan international Takefusa Kubo and captain Mikel Oyarzabal.
Inter: Sommer; Darmian, Acerbi, Carlos Augusto; Cuadrado, Frattesi, Calhanoglu, Mkhitaryan, Dimarco; Alexis Sanchez, Thuram
Inter bench: Di Gennaro, Audero, Arnautovic, Lautaro Martinez, Klaassen, Asllani, Barella, Bisseck, Stabile, Bastoni
Real Sociedad: Remiro; H Traore, Zubeldia, Le Normand, Aihen Munoz; Zakharyan, Zubimendi, Merino; Kubo, Sadiq, Oyarzabal
Real Sociedad bench: Unai Marrero, Odriozola, Elustondo, Carlos Fernandez, Olasagasti, Tierney, Pacheco, Andre Silva, Turrientes, Gonzalez, Magunacelaya, Dadie
Ref: Schärer (SUI)
12-12-2023 20:00 MatchDay 6 San Siro Stadium (Stadio Giuseppe Meazza)
29-11-2023 | Benfica | D | 3 - 3 | ||
08-11-2023 | RB Salzburg | W | 0 - 1 | ||
24-10-2023 | RB Salzburg | W | 2 - 1 | ||
03-10-2023 | Benfica | W | 1 - 0 | ||
20-09-2023 | Real Sociedad | D | 1 - 1 |
24-10-2023 | RB Salzburg | W | 2 - 1 | ||
03-10-2023 | Benfica | W | 1 - 0 |
0 - 0 | D | RB Salzburg | 29-11-2023 | ||
3 - 1 | W | Benfica | 08-11-2023 | ||
0 - 1 | W | Benfica | 24-10-2023 | ||
0 - 2 | W | RB Salzburg | 03-10-2023 | ||
1 - 1 | D | Inter | 20-09-2023 |
0 - 1 | W | Benfica |
24-10-2023 0 - 2 W RB Salzburg
03-10-2023
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