Originally posted on Football Nation  |  Last updated 10/7/12

Welcome to San Francisco, Buffalo! Maybe you can stay a little longer. Like a few more games. If Sunday's game was an indication of how the two teams match-up, the 49ers would love to play a best of five game series with the Bills.

One team boasts a prolific offense (the Bills), and another team boasts a terrific defense (the 49ers), yet on Sunday at Candlestick Park in San Francisco, one team boasted both a prolific offense and a terrific defense.

The score was evident for how the game played out, a 45-3 San Francisco thrashing of Buffalo, and here is what can be taken away from the game:

1. The San Francisco 49ers had a record-setting day in terms of offensive yardage gained. Never before in the storied and glorious history did they put up the stats witnessed on Sunday. The 49ers became the first team in NFL history pull off 300 yards passing and 300 yards rushing in the same game. All told, San Francisco gained 621 total yards through the air and on the ground.

Buffalo left San Francisco with a hole through them, as the 49ers marched up and down the field at will, as if they were scrimmaging against a junior college team. We learned that the 49ers offense can be good (record-setting good), and the Bills defense can be bad (very, very bad).

2. The Buffalo Bills may have spent a lot of money in the offseason to shore up their defensive deficiencies, but that money may have been better spent buying a sightseeing tour company for Niagara Falls.

The Bills signed defensive end Mario Williams to a six year contract worth up to $100 million, but looking at the recent performance of Williams and the rest of the Bills defense, there still is a long way to go to recover even a portion of that investment.

The Bills defense was dragged up and down the field for the second week in a row, and the way things are looking now, Buffalo may have hard time circling the wagons as ESPN analyst Chris Berman likes to say.

3. Alex Smith can play quarterback with anyone in the NFL. Smith may not be the most mobile quarterback in the league, nor possess the strongest arm, nor be the most accurate passer the NFL can showcase, but take a look at Smith's stats week in and week out and you will find a very solid and trustworthy quarterback who leads his team to victory more times than naught.

On Sunday, Alex Smith threw for a season high 303 yards and tossed three touchdowns to boot. Smith did not throw an interception, and guided the 49ers to scoring drives throughout the afternoon, and proved once again to his detractors that San Francisco can win, and dominate with Alex Smith as the quarterback.

4. Ryan Fitzpatrick and the high-flying Buffalo Bills can be limited in their offensive output, which is bad news for the Bills. Based on recent performances, the Buffalo Bills are going to have to outscore their opponents seemingly every week if they stand a chance to win the game.

Buffalo has some good play-makers in quarterback Ryan Fitzpatrick, running backs Fred Jackson and C.J. Spiller, and wide receiver Stevie Johnson, but without these guys putting up monster numbers each week the Bills will find it difficult to win many more games.

5. The San Francisco 49ers seem to be on a mission so far in this young NFL season. San Francisco seems determined to match their stalwart defense with a potent offense that will lead them to Super Sunday early next year.

The 49ers now throw the ball regularly with success and this, combined with their solid running game, leaves opponents no longer being able to focus on the run game only and daring quarterback Alex Smith to beat them.

Alex beats them. Regularly.

The San Francisco 49ers showed people how good they can be when they are clicking on all cylinders. Unfortunately for Bills fans, Buffalo showed everyone, again, how bad they can be.



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