Week 5 was particularly brutal for NFL injuries with stars like Odell Beckham Jr. and J.J. Watt suffering major injuries. Of course, this is the NFL, so they were far from the only impact players who were hurt to some degree this weekend.
Here's a rundown of the biggest injuries of the week.
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Awuzie re-aggravated a hamstring injury against the Packers and was ruled out for the remainder of the game. He's suffered multiple issues with his hamstring this season.
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Odell Beckham Jr., WR, Giants
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Beckham was diagnosed with a broken ankle after getting rolled up on late in Sunday's game. He will wait for a second opinion before undergoing surgery, and the rest of his season is in doubt.
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Clay was carted off the field on Sunday with a knee injury. Clay has an MCL sprain and maybe more, meaning he'll be out at least a few weeks, which is a crushing blow for a Bills squad that is already without No. 1 wideout Jordan Matthews.
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Conley was carted off the field late in Sunday's game with an Achilles injury after recovering an onside kick. DeMarcus Robinson will likely see more snaps with the chance Conley is done for the year.
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Harris will miss the rest of the season with a fractured foot. It's a costly injury for a Giants team that is very thin at wideout.
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Adam Jones, CB, Bengals
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Jones left Sunday's game and was ruled out with a lower back injury. The Bengals are thin at cornerback without him.
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Kelce took a hit to the head just before halftime and wasn't seen during the second half due to a concussion. The Chiefs still managed to score 42 points and will monitor their star tight end.
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Green Bay's rookie cornerback left with a concussion. The Packers still managed a late win against the Cowboys and hope he'll pass the concussion protocol.
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Kirkpatrick was ruled out of Sunday's game with a shoulder injury, in addition to Adam Jones's back injury. His status is uncertain.
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A bad season got worse for Marshall when he suffered an ankle injury on Sunday and was carted off. His status is unclear.
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Mercilus left very early in Sunday's game with a chest issue, reported as a pectoral injury. He was immediately ruled out and is reportedly out for the season with a torn pectoral.
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Ngata left Sunday's game with an elbow injury. The Lions were unsure of the severity after the game.
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Parker didn't return following an ankle injury on Sunday that was diagnosed as a sprain. The Dolphins defeated Tennessee 16-10.
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Powell suffered a calf injury late in the first half of Sunday's game and didn't return to action. The Jets were already without Matt Forte.
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Shepard is considered week to week with an ankle injury. He was one of four wide receiver injuries for the Giants on Sunday.
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Houston's star defensive end suffered a left tibial plateau fracture in the first half of Sunday's game. He's out indefinitely.
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Baltimore's starting running back left during the first drive on Sunday with a calf injury and didn't return. Alex Collins got more work with West out of the game.