Originally written on NESN.com  |  Last updated 11/2/14

LAS VEGAS - NOVEMBER 14: Manny Pacquiao enters the ring before taking on Miguel Cotto during their WBO welterweight title fight at the MGM Grand Garden Arena on November 14, 2009 in Las Vegas, Nevada. (Photo by Al Bello/Getty Images)
Sometimes, all it takes is one punch. Manny Pacquiao‘s near-sterling boxing record took just as hard a hit as the Filipino star Saturday night, with Juan Manuel Marquez landing a well-placed counterpunch to defeat the foe he had seen so many times before. Pacquiao had fought his way back into the round and seemed to have an edge on Marquez. But as he took a swing with his right hand in the sixth round, Marquez dodged and then unleashed a massive punch from his own right hand, knocking out Pacquiao, who fell face-first onto the canvas. “I knew Manny could knock me out at any time,” Marquez said, according to Yahoo! Sports. “I threw the perfect punch.” It was the fourth fight between Pacquiao and Marquez, and with Marquez’s victory, there’s already speculation that the two will meet again. Pacquiao, who turns 34 on Dec. 17, reportedly didn’t put as much time into preparation for this fight as he has for others. Marquez also packed on some more bulk before the two met this time around. Marquez notched his upset in front of a crowd that included former presidential candidate Mitt Romney, Dodgers part owner Magic Johnson and rapper 50 Cent. Check out the highlights below. Photo of the Day Hey, some of those guys look like they could play for the Red Sox. David Ortiz is joined at his charity golf outing by Terry Francona, Kevin Millar, Tim Wakefield, Pedro Martinez and Johnny Damon. Photo via Twitter/@bradfo Quote of the Day “I have been dreaming about this since I was a kid, running around the backyard pretending I was Doug Flutie, throwing Hail Marys to my dad.” – “Johnny Football” Manziel, on winning the Heisman Trophy on Saturday Tweet of the Day And sometimes, you get knocked out. “It’s a game. Sometimes you win, sometimes you lose.” Manny Pacquiao— JUDE ANGELES (@Judesinahon) December 09, 2012 Video of the Day John Calipari doesn’t want anyone else joining in on his wild hand-waving and finger-pointing rage.
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