Askia Booker led seven Colorado players in double figures with 15 points and the Buffaloes pulled away in the second half for a 94-70 victory over Jackson State on Saturday in the first meeting between the schools.
Xavier Talton and Dustin Thomas scored 13 points apiece for Colorado (3-1), which has won three in a row since a season-opening loss to Baylor.
Javeres Brent led Jackson State, which is in the midst of a five-game road trip, with 20 points. Julysses Nobles added 16 points for the Tigers (1-3).
Up by 11 at halftime, the Buffaloes opened the second half with 10-4 burst that extended their lead to 56-39.
The Tigers scored eight of the next 10 points to pull to within 11 again only to see Colorado pull away with another run, punctuated by another 3-pointer by Booker that put the Buffs in front 66-49 with 12:02 left.