Kyle Schwarber had a go-ahead two-run single in a four-run seventh inning and Indiana went on to beat Florida State 10-9 Saturday in the first game of the Tallahassee Super Regional.
Schwarber, who also had a two-run homer in the fourth, put Indiana up 7-6 with his hit in the seventh.
Indiana (47-14) can advance to its first College World Series with a win on Sunday. If the Seminoles (47-16) win, a deciding game would be played Monday.
The Hoosiers' big inning came against relievers Gage Smith (4-2) and Billy Strode, who gave up just three hits in the inning but the Seminoles committed two throwing errors.
John Nogowski's two-run homer in the eighth trimmed Indiana's lead to 10-8. DJ Stewart added an RBI single in the ninth, but Indiana's Will Coursen-Carr induced a pair of flyouts to end the game.
Brian Korte (1-0) pitched one-third an inning.