Based on how they've performed at PNC Park coupled with San Diego's play on the road, the Pittsburgh Pirates should be able to end their lengthy home losing streak to the Padres.
Of course, if scheduled starter James McDonald's struggles continue, another defeat could be imminent.
McDonald again hopes to break out of his second-half funk and help the Pirates avoid losing a 10th straight home game to San Diego in Friday night's series opener.
Pittsburgh (63-48) lost 6-3 to Arizona on Thursday, but it's still in control of the NL's second wild-card spot thanks largely to a major league-best 35-18 home record. It has lost only one of its last 10 series at PNC Park and is one victory away from matching last season's win total there.
The Padres (49-64), meanwhile, own the majors' fifth-worst road record at 22-34, and have lost five of six away from San Diego.
Despite their recent road woes, they've been quite comfortable playing in Pittsburgh.