Dayan Viciedo hit a solo home run with one out in the 10th inning Sunday, lifting the Chicago White Sox over the Seattle Mariners 4-3.
Viciedo hit the first game-ending homer of his career, connecting against Kameron Loe (1-1).
Alex Rios homered in his career-best third straight game and Adam Dunn also homered for Chicago.
The White Sox improved to 26-5 against Seattle since 2010. Seattle hasn't won a series at U.S. Cellular Field since August 2007.
Addison Reed (1-0) pitched a scoreless 10th.
Michael Morse hit his fifth home run for Seattle. Kendrys Morales hit his first for the Mariners.
White Sox starter Chris Sale allowed three runs, including two homers, in seven innings. He struck out seven and walked two.
Mariners starter Hisashi Iwakuma gave up three runs and struck out three in eight innings.
Rios tied it 3-all with a solo shot off Iwakuma in the seventh. Iwakuma had retired 16 batters in a row before the home run.
The Mariners took a 3-2 lead in the sixth when Mor...