Blowing a 14-point fourth-quarter lead to their division rivals, the Memphis Grizzlies missed out on a chance to make an early statement.
The Grizzlies have an opportunity to bounce back on Tuesday night when they host the Phoenix Suns, who will try to avoid a fourth straight defeat.
While the Spurs' Big Three were refreshed following two days off that ultimately cost the team a 250,000 fine, the Grizzlies were playing the second half of a back-to-back on Saturday night.
Memphis (12-3) led 76-62 with 9:41 to play, but couldn't hold on in a 99-95 overtime loss at two-time Southwest Division champ San Antonio.
"We don't use any excuses here," said guard Mike Conley, who finished with 18 points and 12 assists. "We felt like we had a chance to win the game regardless of back-to-back or resting."
The Grizzlies, though, appear to be in a better position against the Suns (7-11). Since the season opener, they're 4-0 with at least two days rest.