John Skelton won a long, tight competition to become starting quarterback for the Arizona Cardinals, only to go down with a sprained ankle in the final minutes of the season opener.
Five games and another quarterback injury later, Skelton is starting again.
Kevin Kolb, who replaced Skelton in the opener and helped the Cardinals get off to a 4-0 start, is out indefinitely with rib and chest injuries sustained when Arizona was beaten at home by Buffalo 19-16 in overtime.
It was the Cardinals' second straight loss.
Now Skelton steps in to lead the Cardinals to Minnesota to face the Vikings on Sunday and try to figure out how to succeed behind an offensive line that allowed Kolb to be sacked 22 times in the last three games.