Indianapolis Colts outside linebacker Robert Mathis will miss two to three weeks with a sprained left knee. The Indianapolis Star reported Wednesday that Mathis might be sidelined for several weeks and defensive coordinator Greg Manusky acknowledged the unfortunate news Thursday. The injury occurred during the Colts' win Sunday over Green Bay when Mathis twisted the knee in the fourth quarter on a sack of Packers quarterback Aaron Rodgers. Mathis leads the team with five sacks this season. "It would have been great to have him up this week," Manusky said. "But the next guy's got to stand up and go out there and perform at a high level."