Originally written on Football Nation  |  Last updated 9/14/12
Detroit Lions @ San Francisco 49ersA game being called the "handshake bowl", Jim Schwartz vs. Jim Harbaugh round 2! Postgame fireworks will only be the exclamation point on a game that is sure to be thrilling.The Detroit Lions (1-0) have one of the most prolific offenses in the league. Weapons surround Matthew Stafford with the potential to blow up at any moment.Matthew Stafford was a little of his game last week with three interceptions and only one touchdown. The yardage was there however (355). This week's matchup is scary against the No. 1 defense in the league, this does not change his must-start status, however.Kevin Smith had a good game a week ago but simply put, he is playing the 49ers. You don't play running backs facing the 49ers. Especially if the ratio of pass to run is 48:18 once again.Calvin Johnson sat out Wednesday's practice but returned Thursday and Friday, another must-start.Titus Young is inconsistent and you don't want to play him in this matchup. Nate Burleson...
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