Saints coach Sean Payton says tight end Jimmy Graham, who leads the team in receiving, has missed Thursday's practice with a sore right ankle.
Graham has 39 catches for 620 yards and three touchdowns, and last week became only the second tight end to have four straight games in the same season with 100 yards or more receiving, matching the feat accomplished by Tony Gonzalez in 2000.
Graham practiced on Wednesday, but Payton says the tight end was having ankle soreness afterward and was given Thursday to rest.
Graham is in his second NFL season out of Miami, where he played power forward for the basketball team for four years before playing one season of college football.
The Saints host Indianapolis on Sunday night.