Indianapolis released its longest-tenured player, long snapper Justin Snow, as it reached the NFL roster limit of 53 on Friday.
Snow had played in 192 consecutive games - the second-longest streak in franchise history behind Peyton Manning.
The Colts also waived receivers Kashif Moore and Jeremy Ross; running back Darren Evans; tight ends Andre Smith and Kyle Miller; offensive linemen Steven Baker, Hayworth Hicks, Mike Tepper and Zane Taylor; defensive linemen Chigbo Anunoby and Jason Shirley; linebackers Greg Lloyd and Jerry Brown and safety Latarrius Thomas.
Running back Deji Karim, defensive end James Aiono, linebacker Tim Fugger and defensive backs Brandon King and Mike Newton were waived-injured.
Receiver Jabin Sambrano and cornerback Korey Lindsey were put on injured reserve. Offensive tackle George Foster was released from injured reserve.