San Francisco 49ers (10-2) vs. Arizona Cardinals (5-7)

The 49ers completely shut down the Cardinals, 26-0 last weekend.  They beat the Cardinals 23-7 in San Francisco just three weeks ago.  That was the only game the Cardinals have lot in their last five games and they will have Kevin Kolb under center this weekend.  Here is a look at the matchups in this game: When the 49ers have the ball:  The 49ers will likely go with the conservative approach as they ran the ball 42 times in the first meeting between these two teams.  The Cardinals are giving up 119.4 yards rushing per game and 4.0 yards per carry, so Frank Gore should have a good game this Sunday.  Look for Kendall Hunter to also be involved in the running attack this weekend in an attempt to keep Gore healthy.  Alex Smith should have time to throw the ball this weekend, so look for him to continue to target WRs Michael Crabtree, Kyle Williams and Ted Ginn down the field.  The Cardinals are giving up 251.1 yards passing per game, so the Niners should be o.k. this weekend when throw...