Week 1: @ GB
The Niners will have their stones tested right out of the gate at Lambeau Field.
The Packers' defense met with a lot of criticism last season, and they'll have their hands full with Frank Gore, Vernon Davis, and Randy Moss. How much Alex Smith improves will obviously play a big role in whether or not the Niners win.
Week 2: vs. DET
The Lions will likely be looking to dish up some cold revenge in prime time after suffering their first defeat of the 2011 season at the hands of the 49ers. I'm sure Jim Schwartz would like nothing more than to give Jim Harbaugh a nice, big slap on the back after the game.
Week 3: @ MIN
San Francisco's defense will have their work cut out for them if Adrian Peterson is carrying the ball. How effective Christian Ponder and the Vikings' offense will be in the 2012 season is still up in the air, but labeling this game an easy win for the Niners could be a mistake.
Week 4: @ NYJ
Tebow. There I mentioned him. The 49e...