Texans defensive end Tim Jamison left Sunday night's game against Green Bay with a right Achilles injury and the team said he would not return.
The 6-foot-3, 285-pound Jamison played in each of the Texans' first five games, backing up J.J. Watt. Jamison had nine tackles, including a sack, and a deflected pass this season.
Packers linebacker Nick Perry left in the second quarter with a knee injury, and the team said his return was questionable. Perry was the Packers' fifth-leading tackler (28) and had two sacks through the first five games.
Green Bay middle linebacker D.J. Smith limped off the field later in the second quarter with a right knee injury, and the team said he was doubtful to return.
Texans right guard Antoine Caldwell left before halftime with a concussion.