Originally written on Buffalo Wins  |  Last updated 11/10/14

Jason: 35 - 10, 49ers:  Why couldn't the Ryder Cup have been this Sunday instead?  This one has the potential to enter into the pantheon of All-Time Bills Road Game Debacles.  Anticipating at least one San Francisco return for a TD, either defense or kick teams. Give the points.

Frank:  38-16, 49ers: If Buffalo is serious about showing folks they're legitimate, they've got to start doing it soon. This week, they're not going to do that with a win, though. They can show progress and promise by putting up a fight, by adapting, and by not giving up once San Francisco starts to pull away - which they'll do early. They're playing one of the top few teams in the league Sunday and are traveling to the left coast to do so. I don't see any way Chan, Ryan, and the boys walk away with a win in this one.

Aaron: 34-17, 49ers: The Bills got physically manhandled in the running game by the usual pass-happy Pats. They were the same old Bills' defense, getting pushed around by a mediocre offensive line. Good thing they'll get some rest this week, as they have the luxury of playing the 49ers, who like to spread 'em out and shy away from both the running game and playing the most imposing defense the league has seen in the last decade. Wait, they don't have Steve Young and Jerry Rice anymore?

Alex: 27-13 49ers: "Boy, Mario sure is a trooper for playing through this wrist injury." — Nobody

Chris: 30-17, 49ers:  Niners are scary good right now. This has a perfect storm kind of feel to it. San Fran can run the ball down anyone's throat and it seems as if the Bills proved they might struggle with such an offense. Plus, the Bills are without two starting offensive linemen and are facing a very intimidating defense. Maybe if they don't let Fitzpatrick throw the ball more than 25 times this could be a close game. If CJ Spiller and Fred Jackson control the game for the Bills, they will have a punchers chance. It also will help if the defense can adjust to the schemes they're facing as the game progresses.

Brandon: 27-6, 49ers: If you're looking for some optimism, you came to the wrong place. Fitzpatrick throws five picks and the Bills fail to score a touchdown. Not a day goes by when I don't wish Patrick Willis would have fallen just one more goddamn spot in the 2007 Draft. Then again, the Bills probably would have still taken Marshawn Lynch... I suppose we can find a bright side to all this: At least the Bills didn't get the chance to draft JaMarcus Russell. Maybe someone should conjure up a drinking game for this one. That way, ya know, we can justify wasting three hours of our Sunday afternoons. Each time a Bill complains: Down your drink!

Mike Tracz: 27-13, 49ers: Unless your name is Adrian Peterson you aren't running on the 49ers, so the Bills' success (or lack thereof) will be largely dependent on whether Good Fitz or Bad Fitz shows up.  Against a defense this good, Bad Fitz might be good for 20 or so picks.  Meanwhile, after getting gashed for a million yards on the ground against New England last week, the Bills get to face an offense that's built entirely on the running game.  Oh yeah, and you know how the Bills can never seem to stop tight ends?  Vernon Davis.  Good luck with that.

Michael Necci: 41-14, 49ers: Why that score? Because that is the average final score your Buffalo Bills have lost by since their last win on the West Coast. Their last win played in Pacific Standard Time was @SF in 2004, a 41-7 win. These next two weeks have disaster written all over them. Brace yourself, it could get ugly.

Joe: 21-10, 49ers: How great was the "No Punt" game from 1992? Kelly vs. Young. Thurman vs. Ricky Waters. 1000 yards in offense. Timeless classic. Yeah, something tells me we aren't going to get that this weekend. The 49ers have 15 1st round picks on their roster! 15! Randy Moss, Tedd Ginn Jr., Justin Smith, Carlos Rogers, Alex Smith, Donte Whitner, Patrick Willis, Vernon Davis, Randy Moss, Joe Staley, Anthony Davis, Michael Crabtree, Mike Iupati, Aldon Smith, and AJ Jenkins. The Bills? 6. McKelvin, Wood, Spiller, Dareus, Mario Williams, and Gilmore. The 49ers are lethal when it comes to their defense. They rank in the top 6 in points, rushing yards, passing yards and rushing yards allowed. Only way the Bills can win this game is if they stop Frank Gore and make Alex Smith beat them. The 49ers have given up the 6th most sacks this year (12) while only attempting 114 passes, which ranks 30th in the NFL. Keep in mind Smith was sacked 44 times last year, which was 26th most in the NFL. So, the Bills should be able to get pressure. Right? RIGHT?! Even if they do though, I still hate the Bills' offense in this one. There are no offensive matchups in their favor. Nothing to exploit. I guess we can see if Donte Whitner still can't cover? I also think Spiller/Fred are still hurting which doesn't help matters.

MORE FROM YARDBARKER

Devon Still accused of not paying child support

Giants reportedly in talks with Max Scherzer, Chase Headley

Report: Robert Griffin III benched by Redskins for McCoy

Dice-K Matsuzaka headed back to Japan

Lovie Smith: 2-9 Bucs are still in playoff contention

UCLA QB Brett Hundley likely to enter NFL draft

LIKE WHAT YOU SEE?
GET THE DAILY NEWSLETTER:

Bills will return to Ralph Wilson Stadium for Sunday's game

Miller to Oregon transfer rumor originates on Reddit

Valencia FC ditches bat logo amidst DC Comics challenge

Paul Pierce: Celtics' Big Three was like 'Holy Trinity'

Cubs reportedly offer Jon Lester more than $135 million

Colin Kaepernick: Jim Harbaugh will be back in 2015

10 greatest Thanksgiving Day games in NFL history

Derrick Rose leaves game with hamstring tightness

WATCH: Ty Lawson drops Kirk Hinrich to the floor

Alabama DL trolls Auburn with Instagram photo

Rockies pitcher takes shot at former Astros pitcher

WATCH: Paul Pierce signs autograph during game

Jeremy Hill asks great question about alma mater LSU

NBA rookie rankings after 1st month of 2014-15 season

Statistic about Derrick Rose, Jimmy Butler very revealing

Aaron Rodgers blasts those who accused him of trolling Vikings

The century's 10 most one-sided college football rivalries

WATCH: The Good, the Bad and the Ugly of NBA's first month

NFL News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!

By clicking "Sign Me Up", you have read and agreed to the Fox Sports Digital Privacy Policy and Terms of Use. You can opt out at any time. For more information, please see our Privacy Policy.

Rose leaves with injury again

WATCH: Pierce signs for fan during game

Report: McCoy to start over RG3

Braxton Miller headed to Oregon?

10 most one-sided college football rivalries

Pierce: C's Big Three like 'Holy Trinity'

Maclin unhappy with Cooper comments

Post-Week 13 CFB Playoff projection

What has Masai Ujiri built in Toronto?

How L.A. should replace Hanley

Lester, Red Sox still talking contract

Why each NFL team should be thankful

Today's Best Stuff
For Bloggers

Join the Yardbarker Network for more promotion, traffic, and money.

Company Info
Help
What is Yardbarker?

Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.