Dallas Cowboys quarterback Dak Prescott hugs Philadelphia Eagles quarterback Jalen Hurts after the game at AT&T Stadium. Tim Heitman-Imagn Images

Cowboys vs Eagles Week 1 odds for 2025 opener: Dallas is heavy underdog

Originally posted on Dallas Cowboys on SI
By Josh Sanchez | Last updated Sep 1, 2025 11:17 AM ET

Dallas Cowboys Nation, we've officially made it to game week. It's been a chaotic few days with the roster gymnastics and reshuffling going on, including the Micah Parsons trade to the Green Bay Packers, which sent shockwaves through the NFL.

The Cowboys take the field in just a matter of days, traveling to Lincoln Financial Field to face the Super Bowl champion Philadelphia Eagles.

Because Dallas is taking the field after ditching its best player, the oddsmakers aren't feeling too good about the Cowboys' chances.

In fact, the Cowboys are more than a one touchdown underdog.

According to ESPN BET, the Eagles are significant 7.5-point favorites over the visiting Cowboys, while the over/under is just 47.5 total points.

The moneyline has Dallas as a +300 dog, while Philly is a -400 favorite.

That means a $100 wager on the Cowboys would land you a $300 profit, while you would have to risk $400 for a $100 payday by betting on the Eagles.

A full look at the betting odds and information for Thursday night's game can be seen below.

Dallas Cowboys at Philadelphia Eagles, Week 1 betting odds & viewing info

Date: Thursday, September 4, 2025
Start Time: 8:20 p.m. ET
Location: Philadelphia, Pennsylvania
Venue: Lincoln Financial Field
TV Info: NBC
Live Stream: Peacock

Betting Odds: Eagles -7.5 | O/U: 47.5 (odds via ESPN BET)
Moneyline: Eagles -400, Cowboys +300

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.