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On YouTubeSan Francisco 49ers News / 49ers Webzone / September 4
Kyle Shanahan addresses Isaac Guerendo's role on 49ers depth chart
San Francisco 49ers running back Isaac Guerendo showed promise as a rookie last season, averaging five yards per carry. Injuries across the roster created opportunities for the young back, who finished the year with 420 rushing yards and four touchdowns in 16 games (three starts).
San Francisco 49ers News / San Francisco 49ers on SI / September 3
Why the 49ers Gave up on Isaac Guerendo for Brian Robinson Jr.
When the San Francisco 49ers traded for Brian Robinson Jr., it effectively ended any hope for Isaac Guerendo becoming the No. 2 running back. The position was in a desperate spot throughout training camp due to countless injuries.
San Francisco 49ers News / 49ers Webzone / August 25
49ers' Brian Robinson confident he and Christian McCaffrey will be NFL's 'best duo'
Running back Brian Robinson Jr. spoke to reporters for the first time since being traded from the Washington Commanders to the San Francisco 49ers. Robinson is expected to serve as the primary backup to Christian McCaffrey, strengthening a running back room that also includes second-year player Isaac Guerendo.
The 'NFL passer rating leaders' quiz
How many of the NFL's yearly leaders in passer rating in the Super Bowl era (since 1966) can you name in seven minutes?
NFL News / NFLTradeRumors.co / August 22
Commanders Trading RB Brian Robinson To 49ers
According to Adam Schefter, the Commanders are trading RB Brian Robinson to the 49ers in exchange for a 2026 sixth-round pick. Yesterday, Ben Standig named San Francisco as a team to watch, given their injuries.
32 notable NFL QBs who were acquired well into the season
It's uncommon, but not unheard of, for notable QBs to change teams -- via trade, free agency, or waiver claim -- at the 11th hour or during a season. Here are the top instances of QBs relocating late and making an impact that season.
San Francisco 49ers News / San Francisco 49ers on SI / August 5
49ers Must Start Viewing This RB as an Injury-Prone Player
Injuries have been running rampant on the San Francisco 49ers since training camp began. They can’t even continue their kicker competition or have three quarterbacks because of the injuries.
San Francisco 49ers News / Total Apex Sports / August 4
San Francisco 49ers: Injuries Piling Up As First Preseason Game Looms
The San Francisco 49ers launched into the 2025 NFL training camp with high hopes for the upcoming season. But as practices ramp up at Levi’s Stadium, the focus has shifted from perfecting plays to managing an unsettling wave of injuries.
San Francisco 49ers News / 49ers Webzone / August 4
49ers injuries: Kyle Shanahan provides updates on Isaac Guerendo, Kyle Juszczyk, several others
San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Monday's practice—the team's first of the week as it prepares for Saturday's preseason opener against the Denver Broncos.
San Francisco 49ers News / 49ers Webzone / August 2
49ers' Puni predicts 'crazy one-two punch' with McCaffrey and Guerendo
San Francisco 49ers guard Dominick Puni admits his rookie season was a whirlwind, revealing he wasn't fully prepared for the physical toll of a 17-game NFL schedule.
Why Isaac Guerendo Could be the 49ers' Breakout Player this Year
Deebo Samuel is gone and Brandon Aiyuk might never be the same after tearing his ACL, MCL and meniscus. Which means the 49ers need someone new to step up and become a factor on offense.
Who Will be the 49ers' Backup Running Back this Year?
The backup running back is an important player on the 49ers. That's because their starter, Christian McCaffrey, gets injured frequently. That's what happened when he played for the Carolina Panthers and it's what happened last season on the 49ers.
2026 first-round NFL mock draft: Three QBs in the top 10
With the month of September in the books, both the top college prospects and 2026 NFL draft order are coming into focus. Here's a look at our latest first-round NFL mock draft as of October 13, 2025.
San Francisco 49ers News / 49ers Webzone / May 16
ESPN doesn't expect much from 49ers' Jordan James in Year 1
ESPN's Mike Clay evaluated the landscape for rookie NFL running backs, projecting the potential roles of several first-year players. Among them is Jordan James, whom the San Francisco 49ers selected in the fifth round of the draft out of Oregon.
Will the 49ers Trade Running Back Isaac Guerendo this Offseason?
Just a year ago, the 49ers traded up to take Isaac Guerendo in Round 4. Now, he might not make their 53-man roster this year. That's why Pro Football Network lists Guerendo as a surprise trade candidate this offseason.
San Francisco 49ers News / 49ers Webzone / April 23
Isaac Guerendo receives praise from star 49ers teammate
Isaac Guerendo made an impression during his 2024 rookie campaign, averaging five yards per carry while stepping up after injuries depleted the San Francisco 49ers' running back room.
NFL News / NFLTradeRumors.co / April 11
NFC Notes: Isaac Guerendo, Bryce Young, 49ers, Cardinals, Panthers
The 49ers traded RB Jordan Mason, which will open up a backup role for RB Isaac Guerendo. San Francisco HC Kyle Shanahan outlined what he liked about Guerendo from his 2024 performance.
San Francisco 49ers News / San Francisco 49ers on SI / April 2
Large Expectations Loom for 49ers RB Isaac Guerendo in 2025
San Francisco 49ers head coach Kyle Shanahan spoke for slightly over 30 minutes at the NFL owners meeting. During his availability, he gave an interesting answer on the running back position.
College Football News / The 33rd Team / March 1
2025 Dynasty Fantasy Football: Buy Or Sell Combine Hype On Biggest Breakouts
Saturday was the big day at the NFL Combine as the quarterbacks, running backs, and wide receivers worked out in Indianapolis. While several top-end receivers and tight ends didn’t end up performing, there were plenty of standouts from the workouts.
San Francisco 49ers News / 49ers Webzone / January 6
MRI reveals 49ers RB Isaac Guerendo suffered MCL, ankle sprains
San Francisco 49ers rookie running back Isaac Guerendo shared positive news on Monday morning, revealing via social media that he avoided a dreaded ACL injury, which would have jeopardized his 2025 season.
San Francisco 49ers News / NFLTradeRumors.co / January 5
49ers RB Isaac Guerendo Suffers Left Knee & Ankle Injury
49ers RB Isaac Guerendo was carted off the field at the start of the final game of the season with a left knee injury that appeared to be serious. San Francisco quickly ruled him out for the remainder of the game with a knee and ankle injury.
San Francisco 49ers News / Field Level Media / December 19
Report: 49ers RB Isaac Guerendo likely out vs. Dolphins
San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the 49ers' 12-6 loss to the Los Angeles Rams last Thursday.
San Francisco 49ers News / San Francisco 49ers on SI / December 10
49ers-Rams Injury Report: Isaac Guerendo Trending Down
Well this isn't good. Rookie running back Isaac Guerendo is not participating in Tuesday's practice session with the San Francisco 49ers. Guerendo is nursing a foot sprain that he sustained in the blowout win this past Sunday against the Chicago Bears.
San Francisco 49ers News / 49ers Webzone / December 9
49ers rookie Isaac Guerendo optimistic about foot injury
San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game against the Chicago Bears with a potential foot sprain.
San Francisco 49ers News / 49ers Webzone / October 29
49ers RB Isaac Guerendo nominated for Pepsi Zero Sugar Rookie of the Week award
San Francisco 49ers running back Isaac Guerendo has been nominated for the Pepsi Zero Sugar Rookie of the Week award after an impressive performance in the 49ers' 30-24 Week 8 victory over the Dallas Cowboys.
NFL News / Yardbarker / October 18, 2024
Post-waiver wire fantasy football pickups for Week 7
In fantasy football, opportunity is everything. These little-known running backs haven’t seen much action, but thanks to injuries to starting players, they have an excellent chance to break out in Week 7.
San Francisco 49ers News / San Francisco 49ers on SI / October 13, 2024
Can Isaac Guerendo Carry the 49ers Run Game if Jordan Mason Misses Time?
The 49ers wouldn't have beaten the Seahawks this past Thursday night without rookie running back Isaac Guerendo. The 49ers had a 20-point lead, but starting running back Jordan Mason left the game with a sprained AC joint in his shoulder.
NFL News / Yardbarker / October 11, 2024
'TNF' takeaways: Rookies help 49ers avoid another epic collapse
The San Francisco 49ers avoided another epic collapse, earning a 36-24 victory over the Seattle Seahawks on "Thursday Night Football."
San Francisco 49ers News / A to Z Sports / June 23, 2024
49ers coach sets high expectations for rookie Isaac Guerendo with extremely intriguing comparison
The San Francisco 49ers showed how highly they think of Isaac Guerendo's potential when they traded two fifth-round picks to move up in the fourth round of the 2024 NFL Draft to select him.
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