Isaac Guerendo: Breaking News, Rumors & Highlights

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ESPN’s Jeremy Fowler reports the 49ers are placing RB Isaac Guerendo on the reserve/PUP list with a pec injury, sidelining him for the first four games of the season.

San Francisco 49ers News / San Francisco 49ers on SI / June 3

This Trade Offer is Too Good to be True for the 49ers

The San Francisco 49ers are not satisfied with Isaac Guerendo entering his third NFL season. He is listed as a potential trade candidate by Jacob Infante of Pro Football Network.

San Francisco 49ers News / 49ers Webzone / May 28

49ers injury notes: Isaac Guerendo setback; Nick Bosa, George Kittle updates; Mac Jones doesn't throw

San Francisco 49ers head coach Kyle Shanahan spoke with reporters on Thursday and provided several key injury updates as the team continued organized team activities (OTAs), which began on Wednesday.

Chicago Bears News / Yardbarker Quizzes

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NFL News / Yardbarker

Ranking the NFL's backup quarterbacks for the 2026 season

A few trades have rearranged the NFL's backup quarterback ranks, but the dust has mostly settled. From a mix of recent first-round disappointments, aging vets, and young project types, here is how the league's QB2 ranks look for the 2026 season.

San Francisco 49ers News / Pro Football Rumors / May 28

49ers’ Isaac Guerendo Suffers Pectoral Tear; Team Makes RB Additions

Isaac Guerendo is set to compete for a roster spot this offseason, with the 49ers adding a Day 2 draftee (Kaelon Black) to their backfield — one already housing Jordan James behind Christian McCaffrey.

San Francisco 49ers News / Pro Football Rumors / May 5

RB Isaac Guerendo In Uphill Battle To Make 49ers’ Roster; Latest On Team’s LG Situation

The 49ers have an established track record for mid-round running back investments during the Kyle Shanahan-John Lynch era. Unfortunately for the team, the moves have a high bust rate.

49ers rookie Kaelon Black: Risky pick or intriguing upside?

There has been no shortage of debate surrounding the San Francisco 49ers' first three selections in the 2026 NFL Draft. While third-round pick Romello Height has drawn praise for addressing a clear need along the defensive front, San Francisco's first selection at No.

San Francisco 49ers News / San Francisco 49ers on SI / April 4

Why RB Isaac Guerendo is on Borrowed Time With the 49ers

One of the reasons the San Francisco 49ers didn't ease up on Christian McCaffrey's workload last season was that they didn't have a running back with a similar skill set.

San Francisco 49ers News / 49ers Webzone / February 19

Will this 49ers running back escape Kyle Shanahan's doghouse?

Isaac Guerendo flashed intriguing upside during his rookie season in 2024. The San Francisco 49ers running back totaled 420 rushing yards and four touchdowns on 84 carries, averaging an impressive 5.0 yards per attempt.

San Francisco 49ers News / San Francisco 49ers on SI / December 31

Kyle Shanahan Explains 49ers’ Decision to Make Isaac Guerendo Inactive

2024 was a promising year for running back Isaac Guerendo. He filled in nicely when both Christian McCaffrey and Jordan Mason were injured. It seemed like the San Francisco 49ers finally nailed a running back draft pick.

NFL News / Yardbarker

25 NFL players who could retire after the 2026 season

NFL stars can't play forever, and retirement is coming sooner than later for some of the league's top players. These 25 players could call it quits following the 2026 season.

San Francisco 49ers News / 49ers Webzone / September 4, 2025

Kyle Shanahan addresses Isaac Guerendo's role on 49ers depth chart

San Francisco 49ers running back Isaac Guerendo showed promise as a rookie last season, averaging five yards per carry. Injuries across the roster created opportunities for the young back, who finished the year with 420 rushing yards and four touchdowns in 16 games (three starts).

San Francisco 49ers News / San Francisco 49ers on SI / September 3, 2025

Why the 49ers Gave up on Isaac Guerendo for Brian Robinson Jr.

When the San Francisco 49ers traded for Brian Robinson Jr., it effectively ended any hope for Isaac Guerendo becoming the No. 2 running back. The position was in a desperate spot throughout training camp due to countless injuries.

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San Francisco 49ers News / 49ers Webzone / August 25, 2025

49ers' Brian Robinson confident he and Christian McCaffrey will be NFL's 'best duo'

Running back Brian Robinson Jr. spoke to reporters for the first time since being traded from the Washington Commanders to the San Francisco 49ers. Robinson is expected to serve as the primary backup to Christian McCaffrey, strengthening a running back room that also includes second-year player Isaac Guerendo.

NFL News / NFLTradeRumors.co / August 22, 2025

Commanders Trading RB Brian Robinson To 49ers

According to Adam Schefter, the Commanders are trading RB Brian Robinson to the 49ers in exchange for a 2026 sixth-round pick. Yesterday, Ben Standig named San Francisco as a team to watch, given their injuries.

San Francisco 49ers News / San Francisco 49ers on SI / August 5, 2025

49ers Must Start Viewing This RB as an Injury-Prone Player

Injuries have been running rampant on the San Francisco 49ers since training camp began. They can’t even continue their kicker competition or have three quarterbacks because of the injuries.

San Francisco 49ers News / Total Apex Sports / August 4, 2025

San Francisco 49ers: Injuries Piling Up As First Preseason Game Looms

The San Francisco 49ers launched into the 2025 NFL training camp with high hopes for the upcoming season. But as practices ramp up at Levi’s Stadium, the focus has shifted from perfecting plays to managing an unsettling wave of injuries.

San Francisco 49ers News / 49ers Webzone / August 4, 2025

49ers injuries: Kyle Shanahan provides updates on Isaac Guerendo, Kyle Juszczyk, several others

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Monday's practice—the team's first of the week as it prepares for Saturday's preseason opener against the Denver Broncos.

San Francisco 49ers News / 49ers Webzone / January 6, 2025

MRI reveals 49ers RB Isaac Guerendo suffered MCL, ankle sprains

San Francisco 49ers rookie running back Isaac Guerendo shared positive news on Monday morning, revealing via social media that he avoided a dreaded ACL injury, which would have jeopardized his 2025 season.

San Francisco 49ers News / NFLTradeRumors.co / January 5, 2025

49ers RB Isaac Guerendo Suffers Left Knee & Ankle Injury

49ers RB Isaac Guerendo was carted off the field at the start of the final game of the season with a left knee injury that appeared to be serious. San Francisco quickly ruled him out for the remainder of the game with a knee and ankle injury.

San Francisco 49ers News / NFL on ClutchPoints / December 26, 2024

Isaac Guerendo finally gives 49ers positive injury update

The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update.

San Francisco 49ers News / Field Level Media / December 19, 2024

Report: 49ers RB Isaac Guerendo likely out vs. Dolphins

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the 49ers' 12-6 loss to the Los Angeles Rams last Thursday.

San Francisco 49ers News / 49ers Webzone / December 9, 2024

49ers rookie Isaac Guerendo optimistic about foot injury

San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game against the Chicago Bears with a potential foot sprain.

San Francisco 49ers News / 49ers Webzone / November 6, 2024

Opportunity to Impact: Isaac Guerendo, a New Fan Favorite

Since joining the 49ers, Isaac Guerendo's rise to significant snaps came in the wake of injuries to star running backs Christian McCaffrey, Elijah Mitchell, and the up-and-coming Jordan Mason.

San Francisco 49ers News / 49ers Webzone / October 29, 2024

49ers RB Isaac Guerendo nominated for Pepsi Zero Sugar Rookie of the Week award

San Francisco 49ers running back Isaac Guerendo has been nominated for the Pepsi Zero Sugar Rookie of the Week award after an impressive performance in the 49ers' 30-24 Week 8 victory over the Dallas Cowboys.

NFL News / Yardbarker / October 18, 2024

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San Francisco 49ers News / San Francisco 49ers on SI / October 13, 2024

Can Isaac Guerendo Carry the 49ers Run Game if Jordan Mason Misses Time?

The 49ers wouldn't have beaten the Seahawks this past Thursday night without rookie running back Isaac Guerendo. The 49ers had a 20-point lead, but starting running back Jordan Mason left the game with a sprained AC joint in his shoulder.