-
Follow Us
On Facebook
On Flipboard
On Twitter
Free Newsletters
On YouTubeSan Francisco 49ers News / 49ers Webzone / April 23
Isaac Guerendo receives praise from star 49ers teammate
Isaac Guerendo made an impression during his 2024 rookie campaign, averaging five yards per carry while stepping up after injuries depleted the San Francisco 49ers' running back room.
San Francisco 49ers News / San Francisco 49ers on SI / April 12
Will 49ers Running Back Isaac Guerendo Make a Big Leap in 2025?
One of the 49ers' most intriguing rookies last season was Isaac Guerendo. He didn't play a ton -- just 222 offensive snaps to be exact. And that's because he a backup and he was injured at times.
NFL News / NFLTradeRumors.co / April 11
NFC Notes: Isaac Guerendo, Bryce Young, 49ers, Cardinals, Panthers
The 49ers traded RB Jordan Mason, which will open up a backup role for RB Isaac Guerendo. San Francisco HC Kyle Shanahan outlined what he liked about Guerendo from his 2024 performance.
The 'No. 1 overall pick in the NFL Draft' quiz
How many of the No. 1 overall picks from the NFL Draft since 1966 can you name in six minutes?
San Francisco 49ers News / San Francisco 49ers on SI / April 2
Large Expectations Loom for 49ers RB Isaac Guerendo in 2025
San Francisco 49ers head coach Kyle Shanahan spoke for slightly over 30 minutes at the NFL owners meeting. During his availability, he gave an interesting answer on the running back position.
Post draft, which NFL teams have the best current QB situations?
With an established top tier and some young options revealing themselves last season, here is a look at where clubs' QB depth charts stand. Contracts and long-term outlooks do not factor in here; these rankings apply only to 2025 on-field capabilities.
College Football News / The 33rd Team / March 1
2025 Dynasty Fantasy Football: Buy Or Sell Combine Hype On Biggest Breakouts
Saturday was the big day at the NFL Combine as the quarterbacks, running backs, and wide receivers worked out in Indianapolis. While several top-end receivers and tight ends didn’t end up performing, there were plenty of standouts from the workouts.
San Francisco 49ers News / Niners Wire / February 23
49ers loaded RB room has 1 big question mark that could derail season 
The San Francisco 49ers should have the most talented running back room in the NFL entering the 2025 season. That group, while very good, may also be their downfall.
San Francisco 49ers News / Niners Wire / January 13
No guarantee breakout offensive star returns to 49ers in 2025
San Francisco 49ers running backs Christian McCaffrey and Isaac Guerendo had good news on their late-season injuries, and both appear to be on track to be ready for the start of the 2025 season.
NFL News / NFLTradeRumors.co / January 6
NFC Notes: Isaac Guerendo Injury, Jared Verse, Cardinals, Seahawks
49ers HC Kyle Shanahan said RB Isaac Guerendo’s injury is most likely an MCL sprain and that he will undergo further testing. (Matt Barrows) 49ers WR Jauan Jennings was fined $11,817 for Unnecessary Roughness in Week 17.
San Francisco 49ers News / 49ers Webzone / January 6
MRI reveals 49ers RB Isaac Guerendo suffered MCL, ankle sprains
San Francisco 49ers rookie running back Isaac Guerendo shared positive news on Monday morning, revealing via social media that he avoided a dreaded ACL injury, which would have jeopardized his 2025 season.
San Francisco 49ers News / A to Z Sports / January 6
Injury updates from Christian McCaffrey and Isaac Guerendo offer clarity on 49ers backfield for 2025
Arguably no position on the entire San Francisco 49ers depth chart dealt with as much injury adversity than their running back room. Christian McCaffrey missed most of the year owing to Achilles tendinitis before being sidelined with a knee injury suffered in his fourth game of the season.
San Francisco 49ers News / 49ers Webzone / January 6
49ers RB Isaac Guerendo shares positive injury update
San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. He was carted off to the locker room for evaluation, raising concerns about the severity of his injury.
San Francisco 49ers News / 49ers Webzone / January 5
49ers fear Isaac Guerendo suffered MCL injury, plus other updates
San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The rookie was carted off the field, and the team later announced he had sustained knee and ankle injuries, ruling him out for the remainder of the game.
San Francisco 49ers News / The Spun / January 5
49ers Running Back Carted Off Field After Suffering Gruesome Injury
The San Francisco 49ers are playing their final game of this brutal 2024 season and it's ending in largely the same way as it began: With a starting running back getting seriously injured.
NFL News / A to Z Sports / January 5
49ers rookie suffers injury that could have big implications for 2025 on first series against Cardinals
It didn't take long for the final game of a San Francisco 49ers season defined by injury adversity to be marred by yet another injury. In fact, it only took four plays.
NFL News / Arizona Cardinals on SI / January 5
49ers RB Carted Off Field vs Cardinals
GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury.
San Francisco 49ers News / 49ers Webzone / January 5
49ers vs. Cardinals injury updates: Guerendo, Mustapha, Hufanga ruled out
The San Francisco 49ers entered Sunday's season finale against the Arizona Cardinals with a depleted roster. Quarterback Josh Dobbs took the reins in place of Brock Purdy, who is sidelined with a right elbow contusion and nerve inflammation sustained during last week's matchup against the Detroit Lions.
San Francisco 49ers News / NFLTradeRumors.co / January 5
49ers RB Isaac Guerendo Suffers Left Knee & Ankle Injury
49ers RB Isaac Guerendo was carted off the field at the start of the final game of the season with a left knee injury that appeared to be serious. San Francisco quickly ruled him out for the remainder of the game with a knee and ankle injury.
San Francisco 49ers News / NFL on ClutchPoints / December 28
49ers’ Isaac Guerendo expected to play vs. Lions despite hamstring, foot injuries
With the San Francisco 49ers looking to play spoiler on Monday Night Football against the Detroit Lions, it appears they’ll have Isaac Guerendo back on the field.
San Francisco 49ers News / NFL on ClutchPoints / December 26
Isaac Guerendo finally gives 49ers positive injury update
The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update.
San Francisco 49ers News / Field Level Media / December 19
Report: 49ers RB Isaac Guerendo likely out vs. Dolphins
San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the 49ers' 12-6 loss to the Los Angeles Rams last Thursday.
San Francisco 49ers News / A to Z Sports / December 12
49ers get big news on Isaac Guerendo's status ahead of must-win primetime clash with Rams
Isaac Guerendo sprained his foot in the San Francisco 49ers' Week 14 win over the Chicago Bears last Sunday, but just four days on from that injury, the
San Francisco 49ers News / 49ers Webzone / December 9
49ers rookie Isaac Guerendo optimistic about foot injury
San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game against the Chicago Bears with a potential foot sprain.
San Francisco 49ers News / San Francisco 49ers on SI / December 6
Chris Foerster Says the 49ers Have to be Careful with Isaac Guerendo
Isaac Guerendo has started just one game at running back since he was in the fourth grade. Now the 49ers need him to start the final five games of the season.
San Francisco 49ers News / San Francisco 49ers on SI / October 13
Can Isaac Guerendo Carry the 49ers Run Game if Jordan Mason Misses Time?
The 49ers wouldn't have beaten the Seahawks this past Thursday night without rookie running back Isaac Guerendo. The 49ers had a 20-point lead, but starting running back Jordan Mason left the game with a sprained AC joint in his shoulder.
NFL News / Yardbarker / October 11
'TNF' takeaways: Rookies help 49ers avoid another epic collapse
The San Francisco 49ers avoided another epic collapse, earning a 36-24 victory over the Seattle Seahawks on "Thursday Night Football."
NFL News / Yardbarker / April 30
Five later-round NFL rookies who could thrive in 2024
Here are five players picked in the third round or later in the 2024 NFL Draft who could make an impact and provide more value than their draft spot suggests.
Breaking News
Trending News
Customize Your Newsletter
+
Get the latest news and rumors, customized to your favorite sports and teams. Emailed daily. Always free!
Popular Quizzes
Today's Latest News
MY ACCOUNT SUBSCRIBE ADVERTISE JOBS FAQ
PRIVACY POLICY EDITORIAL POLICY CONTACT US
ABOUT YARDBARKER TERMS OF SERVICE
PRIVACY POLICY EDITORIAL POLICY CONTACT US
ABOUT YARDBARKER TERMS OF SERVICE
Copyright 2025 YB Media, LLC.
All rights reserved.
Use of this website (including any and all parts and
components) constitutes your acceptance of these
Terms of Service and Privacy Policy.
This site is for entertainment purposes only.
There is no gambling offered on this site.
Gambling Problem? Call 1-800-Gambler.
Use of this website (including any and all parts and
components) constitutes your acceptance of these
Terms of Service and Privacy Policy.
This site is for entertainment purposes only.
There is no gambling offered on this site.
Gambling Problem? Call 1-800-Gambler.