Brandon Young scored 19 points as DePaul matched its best start since 2004-05 with an 81-62 victory over Arkansas-Pine Bluff on Saturday night.
The Blue Demons (8-3) used a 22-5 run late in the first half to take a 48-28 advantage at the break and led by 27 points in the second half.
Jeremiah Kelly had 15 points, and Cleveland Melvin and Jamee Crockett added 13 and 10 points, respectively.
Savalace Townsend scored 23 points for the Golden Lions (1-8). Daniel Broughton had 18 points and Mitchell Anderson 14. Broughton and Anderson had 11 rebounds each.
DePaul is 3-0 this year at the on-campus McGrath-Phillips Arena.