Turnovers led to Missouri suffering its worst defeat in four seasons.
If VCU can get its "havoc defense" back in gear - and hit some free throws - the 13th-ranked Tigers could be in for more problems.
Missouri will meet the Rams for the first time on Saturday night in the consolation game of the Battle 4 Atlantis in Nassau, Bahamas.
Looking to advance to the title game after fifth-ranked Duke defeated VCU (3-2) 67-58 in Friday's first semifinal, Missouri (4-1) lost 84-61 to No. 2 Louisville as its season-high 23 turnovers led to 31 Cardinals points.
The Tigers, who lost for the first time in 19 non-conference games under second-year coach Frank Haith, averaged 11.3 turnovers in their first four games and had committed 10 in Thursday's 78-70 quarterfinal victory over Stanford.
"We shot well (46.0 percent). It was the turnovers,'' Haith said Friday following Missouri's most lopsided defeat since a 90-65 loss at then-No. 15 Kansas on March 1, 2009. "We just had some careless plays...