Shawne Alston rushed for two second-half touchdowns, including a 1-yarder with 6:10 left, and West Virginia came from 10 points down to beat Pittsburgh 21-20 on Friday night.
West Virginia sacked Tino Sunseri 10 times, including four on Pittsburgh's final drive, when time ran out on the Panthers.
The Mountaineers (8-3, 4-2 Big East) can earn a share of the conference title next week at South Florida. West Virginia also hold slim hopes for earning the league's automatic BCS berth and would need some help in a tight league race.
Pittsburgh (5-6, 3-3) led 17-7 at halftime but was limited to 80 yards in the second half.