The San Francisco 49ers defense will face Philip Rivers on Monday night. The 44-year-old recently came out of retirement to sign with the Indianapolis Colts following Daniel Jones' season-ending injury.
The San Francisco 49ers are preparing for their Week 16 contest against the Indianapolis Colts on Monday night at Lucas Oil Stadium in Indianapolis, Indiana.
By far, the worst unit on the San Francisco 49ers is their pass rushers. Injuries have decimated this area. They don’t have Nick Bosa and rookie Mykel Williams after they both tore their ACLs earlier in the season.
Wide receiver Brandon Aiyuk may have played his final snap for the San Francisco 49ers. The team recently placed him on the reserve/left squad list after being unable to maintain contact with the wideout.
All NFL players enter the season with high hopes, but sometimes seasons don't go as hoped. These 20 players have been some of the biggest disappointments early in the 2025 season.
San Francisco 49ers wide receiver Ricky Pearsall will not take part in Thursday's practice—the team's first on-field session of the week—as he continues to recover from multiple injuries.
The San Francisco 49ers could clinch a playoff berth before they play the Colts. And they aren’t taking the Colts’ QB situation for granted. Furthermore, here are bold predictions for the Week 16 Monday Night Football clash.
The San Francisco 49ers are 10-4 and riding a four-game winning streak while sitting in third place. While the Seattle Seahawks prepare to host the Los Angeles Rams, the Niners still have a legitimate chance of snagging the 1 seed in the NFC.
Making the playoffs before this season wasn’t a crazy idea to suggest about the San Francisco 49ers. What was a crazy idea is imagining the 49ers making the playoffs without Nick Bosa, Fred Warner, Mykel Williams, and several other key players for a large segment of the season.
With Brandon Aiyuk having been moved to the reserve/left squad list, it is highly likely he has played his final game as a 49er. The veteran wideout’s future will presumably not include time spent in San Francisco in 2026, but it remains to be seen where his next NFL gig will come from.
ESPN analyst Seth Walder set out to project how the final three weeks of the 2025 NFL season—and the postseason—might unfold, turning to ESPN's Football Power Index (FPI) for answers.
For years, Thanksgiving belonged to the NFL, but Christmas belonged to the NBA. Occasionally, an NFL game would fall on Christmas, but it was anomalous, even avoided if possible.
CBS Sports analyst Mike Renner released his latest 2026 NFL mock draft, projecting the San Francisco 49ers to address a clear roster need: the interior offensive line.
The San Francisco 49ers defense has been surviving despite injuries, and a lot of that credit has been given to Robert Saleh. Saleh was always expected to use the 49ers as a pit stop to regain his strong reputation as a head coaching candidate and parlay this into a new job.
Brock Purdy had no excuses against the Tennessee Titans and had to have a big game against their weak pass defense. Fortunately for the San Francisco 49ers, they did not leave that game with more questions about their quarterback as he played well, and the team nearly scored 40 points.
As the San Francisco 49ers prepare for the Indianapolis Colts, they are making sure they have insurance at the most important position. That is because they have brought back an ex-Jets quarterback to back up 49ers quarterback Brock Purdy and Mac Jones on the practice squad, according to NFL insider Tom Pelissero.
San Francisco 49ers wide receiver Jauan Jennings is certainly benefiting from Brock Purdy's return to the lineup following the quarterback's lengthy recovery from a turf toe injury.
At 10–4 with three games remaining in the 2025 NFL regular season, the San Francisco 49ers control their playoff destiny. Nevertheless, the final stretch of the regular season will test whether this team is truly ready for January.
49ers head coach Kyle Shanahan revealed he spoke with Rivers last week when the signal-caller was chatting with San Francisco assistant coach Gus Bradley.