The Saints have placed rookie running back Mark Ingram and linebacker Will Herring on injured reserve, ending their seasons.
Ingram, who won the 2009 Heisman Trophy at Alabama, missed New Orleans' last four games because of a sprained toe on his left foot. Coach Sean Payton says the injury got worse during practice last week.
Ingram carried 122 times for 474 yards and five touchdowns this season. His longest run was a 35-yard touchdown against the New York Giants on Nov. 28.
Herring hobbled off the field favoring his right knee against Carolina last Sunday and Payton says the linebacker has a sprained medial collateral ligament.
Herring, a reserve, was credited with five tackles on defense and four on special teams.
The Saints have signed guard Eric Olsen and linebacker Nate Bussey.