The Indianapolis Colts are currently riding a four-game losing streak. It makes their matchup perfect timing for the San Francisco 49ers. However, the Colts still have facets to be worried about.
The San Francisco 49ers defense is allowing 106.1 rushing yards per game heading into their Week 16 matchup against the Indianapolis Colts, ranking 12th in the NFL.
It’s been an uphill battle for the San Francisco 49ers to inject some life into their pass rush. They’ve been trying their best, but it’s still irrelevant.
Despite a staggering number of injuries on both sides of the ball, the San Francisco 49ers haven’t allowed it to define their season. Sitting at 10–4, they’re on the brink of clinching a playoff berth.
If the San Francisco 49ers win out—highlighted by a potential Week 18 victory over the Seattle Seahawks—they would not only claim the NFC West title but also secure the No.
All NFL players enter the season with high hopes, but sometimes seasons don't go as hoped. These 20 players have been some of the biggest disappointments early in the 2025 season.
San Francisco 49ers wide receiver Ricky Pearsall missed his second straight practice this week, with just one remaining, as the team prepares for its Monday night matchup against the Indianapolis Colts.
The San Francisco 49ers and Brandon Aiyuk drama is almost unbelievable. From demanding a trade to landing a massive payday, the latter scenario would mean earning $30 million per year over the next four seasons, including a $23 million signing bonus and $76 million guaranteed.
The San Francisco 49ers officially control their own destiny when it comes to the number one overall seed in the NFC. They have to win out, and that starts with a road win against the Indianapolis Colts.
The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster is too strong for that. However, this is a team that is falling apart and they have a few glaring issues that can be exposed by the right team.
For years, Thanksgiving belonged to the NFL, but Christmas belonged to the NBA. Occasionally, an NFL game would fall on Christmas, but it was anomalous, even avoided if possible.
It can be tempting for the San Francisco 49ers to overlook the Indianapolis Colts this week. After starting the season 7-1, the Colts have been in a free fall.
Second-year wide receiver Ricky Pearsall has dealt with multiple injuries during the 2025 season, leading some to question whether the San Francisco 49ers playmaker is injury-prone.
Philip Rivers nearly led the Indianapolis Colts to a stunning road victory over the Seattle Seahawks last weekend. It marked the veteran quarterback's first game action since the 2020 NFL season, as he came out of retirement to help Indianapolis after starter Daniel Jones suffered a season-ending injury.
San Francisco 49ers general manager John Lynch joined Bay Area radio station KNBR on Friday morning and was asked to reflect on the ongoing Brandon Aiyuk saga.
The San Francisco 49ers enter Week 16 at 10–4, firmly in playoff position with three games remaining. Read on for 49ers key players to watch as San Francisco faces the struggling Indianapolis Colts.
Philip Rivers' NFL comeback at 44 years of age has been the stuff of legends with teammates celebrating his first touchdown of the season last week and players reacting throughout the league.
After six seasons with the team, it appears San Francisco 49ers wide receiver Brandon Aiyuk will be playing elsewhere in 2026. Ahead of the 2024 season, Aiyuk signed a four-year, $120 million deal to play for San Francisco.
The on-again, off-again relationship between wide receiver Brandon Aiyuk and the San Francisco 49ers looks to be off again. Potentially for good this time.