Originally written on AFC East Daily  |  Last updated 11/25/12
Lead writer Nick St. Denis and AFC East Daily contributors Dan Begnoche and Sean Donovan pick the Buffalo Bills' road contest against the Indianapolis Colts. Nick's take: Bills tailback C.J. Spiller is slated for a big day against a Colts run defense that gives up way too many big scampers. Ryan Fitzpatrick will be good enough, and Buffalo's rushing attack will limit rookie quarterback Andrew Luck and his Colts offense's opportunities by eating a lot of clock. Plus, Buffalo's defensive front pressures Luck into a couple costly mistakes, including a pick to the red-hot Jairus Byrd. Prediction: Bills 27, Colts 23 Dan's take: The difference in this matchup may be which team converts more big plays than it gives up. Buffalo has given up 43 plays of 20 yards or more this year and has completed 39. In comparison, the Colts have given up 37 and converted 48. Indy's specialty has been its passing attack, while Buffalo's has been Spiller's explosive run game. Buffalo's more balanced offense ...
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