Led by coach Diego Simeone and striker Radamel Falcao, Atletico Madrid appears poised to finally break Real Madrid's dominance of the Spanish-capital derby with a long-awaited victory its fans have been coveting for 13 years.
Atletico enters Saturday's game at the Santiago Bernabeu in second place and a commanding eight points ahead of its crosstown rivals after setting its best start in club history with 11 wins, a draw and one defeat.
Falcao says ''I won't be content with a draw. When we go out on the pitch, we go out to win.''
Earlier, league leader Barcelona hosts Athletic Bilbao with forward Lionel Messi only three goals shy of matching Gerd Mueller's scoring milestone of 85 goals in a calendar year.