As if there wasn't enough at stake when two of Europe's biggest teams go at it for a spot in the Champions League quarterfinals, there are a couple of extra reasons for fans to get emotional at Old Trafford on Tuesday.
While one of Manchester United's former heroes returns, the club's longest-serving player is expected to hit another milestone.
And then there's the game itself, with United and Real Madrid level at 1-1 following the first leg of their Champions League last-16 matchup.
It will be Ryan Giggs' 1,000th senior match, and Cristiano Ronaldo's first at United since becoming the world's most expensive player in 2009 by leaving for 80 million pounds (then $131 million).
United captain Patrice Evra spoke to Ronaldo after the first leg and recalls: ''He said it was going to be more difficult to come here. This is his house, so there will be a lot of emotion.''