Agnieszka Radwanska simply can't make it past the fourth round at the US Open, the Grand Slam tournament where she has had the least success.
A 6-4, 6-4 loss to 24th-seeded Ekaterina Makarova of Russia on Sunday night marked the fourth time since 2007 that Radwanska left Flushing Meadows in the fourth round.
The third-seeded Radwanska was the runner-up at Wimbledon in 2012, and has made it to the quarterfinals at both the Australian Open and French Open. But she's never been past the round of 16 in New York, losing in the second round in 2006 and 2009-11, in addition to her fourth-round exits in 2007-08 and each of the past two years.
Makarova had lost all three previous matches she'd played against Radwanska in straight sets. The Russian's victory Sunday allowed her to reach her third Grand Slam quarterfinal -- and first at the US Open.
Next for Makarova is a match against fifth-seeded Li Na of China, the 2011 French Open champion, who eliminated 2008 US Open runner-up Jelena Jankovic 6-3, 6-0 in less than an hour Sunday night.
The winner of Li-Makarova quarterfinal will play the winner of No. 1 Serena Williams vs. No. 18 Carla Suarez Navarro in the semifinals.
Williams won her all-American matchup with No. 15 Sloane Stephens 6-4, 6-1, and Suarez Navarro of Spain defeated No. 8 Angelique Kerber of Germany 4-6, 6-3, 7-6 (3).