On Monday evening, the San Francisco 49ers continued their winning ways with a blowout 48-27 road win over the Indianapolis Colts. It was one of the best games of quarterback Brock Purdy’s career, as he threw for 295 yards and five touchdowns against just one interception.
According to ESPN's Jeremy Fowler, San Francisco 49ers tight end George Kittle is dealing with a "mid-to-low ankle sprain" sustained during Monday night's 48-27 win over the Indianapolis Colts.
It's been surprising to see how successful the San Francisco 49ers have been this year. To be 11-4 with a chance at earning the No. 1 playoff seed in the NFC without Fred Warner, Nick Bosa, and a few other key players for a stretch is astonishing.
Christian McCaffrey and Jonathan Taylor shared a moment on Monday night that resonated far beyond the final score. In a league driven by competition, the respect between two elite running backs became one of the night’s lasting images in an NFL game between the Indianapolis Colts and San Francisco 49ers.
The San Francisco 49ers offense was unstoppable against the Indianapolis Colts in Week 16. Brock Purdy was a playmaker, and the run game looked better than ever.
All NFL players enter the season with high hopes, but sometimes seasons don't go as hoped. These 20 players have been some of the biggest disappointments early in the 2025 season.
San Francisco 49ers rookie defensive tackle CJ West tied teammate Alfred Collins for the top Pro Football Focus pass-rush grade of the game, both posting career-high 91.7 marks.
The San Francisco 49ers avoided playoff talk until beating the Colts. And they got a concerning injury situation in that win. But the offense has been rolling, making explosive NFL history that is leaving punter Thomas Morstead bored out of his mind, according to a post on X by Opta STATS.
The San Francisco 49ers are competing for the top seed in the NFC, thanks in part to players like Kyle Juszczyk. The veteran fullback's importance to his team was underscored on Tuesday when he was voted to the 2026 Pro Bowl Games.
The San Francisco 49ers improved their record to 11-4 after a 48-27 win against the Indianapolis Colts in Week 16. Today, Pro Football Focus released its grades and snap counts from the game.
For years, Thanksgiving belonged to the NFL, but Christmas belonged to the NBA. Occasionally, an NFL game would fall on Christmas, but it was anomalous, even avoided if possible.
The San Francisco 49ers extended their winning streak to five games on Monday night, defeating the Indianapolis Colts 48-27 on the road. With momentum on their side, the 49ers aim to carry that energy into their final two regular-season games and the playoffs.
Brock Purdy had plenty of respect after sharing the field with 44-year-old Philip Rivers on Monday night. The San Francisco quarterback outdueled the veteran in a 48-27 road win over the Indianapolis Colts, but the matchup carried extra meaning for Purdy.
Mama Purdy may have to invite San Francisco 49ers left tackle Trent Williams for Christmas dinner. Williams had nothing but praise for 49ers quarterback Brock Purdy after the Niners’ 48-27 demolition of the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, Ind.—and it caught the attention of Purdy’s mother, Carrie Purdy.
Former Tennessee Vols wide receiver Jauan Jennings went viral during the San Francisco 49ers' win over the Indianapolis Colts on Monday Night Football for his real life "grinch" moment.
The San Francisco 49ers claimed another victim on Monday, but they were also bitten by the injury bug. Niners star tight end George Kittle hurt his ankle in the third quarter of San Francisco’s Week 17 game against the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, Ind., forcing him to leave the field.
Brock Purdy may be angling to become Santa’s backup during the holiday season. The San Francisco 49ers quarterback once again helped organize a Christmas giveaway this month after turning heads with his gift for the 49ers’ offensive line last December.
Monday Night Football often delivers drama, and for the San Francisco 49ers, the end of the first half against the Indianapolis Colts brought a collective gasp from the Faithful.
The San Francisco 49ers are continuing their strong December run on Monday night, rarely needing their punter while controlling the game against the Indianapolis Colts.
The San Francisco 49ers (11-4) kept pace in the NFC playoff picture with a 48-27 win over the Indianapolis Colts (8-7), whose once-bright season has taken a dark turn.
The 49ers’ edge rush group has received a boost in time for tonight’s game. Yetur Gross-Matos has been activated from injured reserve, per a team announcement.
The San Francisco 49ers announced they have activated DE Yetur Gross-Matos from injured reserve. They also elevated CB Eli Apple and LB Eric Kendricks from the practice squad for Monday night’s game against the Colts. Gross-Matos, 27, is a former second-round pick of the Panthers back in 2020.
The San Francisco 49ers placed wide receiver Brandon Aiyuk on the reserve/left squad list last week, raising significant questions about his future in San Francisco.