Originally posted on Midwest Sports Fans  |  Last updated 10/5/11

Already we are nearing the halfway point of the college football season, and Week Six brings another set of marquee matchups.

Thursday night starts the week off with a showdown between a pair of 3-1 Pac 12 teams as Cal heads to Autzen stadium to face the Oregon Ducks.  In addition, one of the best annual rivalries in college football is renewed this weekend when Texas and Oklahoma meet for the 106th time.

Now that most teams have played several tough games, it becomes more clear what each team’s strengths and weaknesses are for betting purposes. With those in mind, here are my picks for this weekend’s top games, plus a fun, free suggestion for anyone who has ever wished they could play fantasy football with college players.

College Football Picks and Betting Lines for Week 6

Thursday, October 6th

Cal v #9 Oregon

  • Cal-Oregon spread: Oregon -24
  •  Cal-Oregon over/under: 63

The last time Oregon played in a nationally televised game, they found themselves on the losing end.  Oregon’s offense has found its way since that week one loss to LSU and is averaging 52 points-per-game. Oregon quarterback Darron Thomas he has thrown 12 touchdown passes with only one interception and is completing over 60 percent of his passes.   LaMichael James rushed for 288 yards last week against Arizona which marks the second consecutive week that he has rushed for over 200 yards.

Cal is 3-1 this season but has had a fairly easy schedule so far and last week lost to Washington 31-23.  Last season Cal stopped Oregon’s high-flying offense and held them to only 15 points in a two point loss.  The Golden Bears have a solid offense this season that is led by Zach Maynard who has thrown for over 1,000 yards and has 10 touchdowns.

I like Oregon to cover the 24 points in this game in what will be a high scoring game.  Cal-Oregon spread Pick: Oregon -24

Friday, October 7th

#5 Boise State v Fresno State

  • Boise State-Fresno spread: Boise State -20.5
  • Boise State-Fresno over/under 58

Boise State looks to stay undefeated this season and continue to keep their dreams of a national championship alive.  Kellen Moore gets another shot on the national stage to prove that he is worthy of being a Heisman Trophy candidate.  This Bronco defense often times gets overlooked  but has been very solid this season.  Their defense has only given up 67 points in 4 games, giving them the nation’s 20th best defense.

Fresno State is coming off a 38-28 loss at home against Ole Miss and their defense couldn’t get a stop all game.  David Carr’s little brother Derek is developing into a solid quarterback for the Bulldogs.  In his first year as a starter, Carr has thrown for 1,291 yards and 10 touchdowns.

Fresno State is not good on defense giving up 32.4 points-per-game and Boise State is not the team you want to face with a struggling defense.  I like Boise State to win big in this game and easily cover the spread.  Boise State-Fresno spread pick: Boise State -20.5

Saturday, October 8th

#3 Oklahoma v #11 Texas

  • Oklahoma-Texas spread: Oklahoma -9.5
  • Oklahome-Texas over/under 57.5

Oklahoma has one of the best offenses in all of college football and is averaging over 555 total yards offense this season.  Sooner QB Landry Jones is heralded as a top pick in next year’s NFL Draft and has completed 71% of his passes for 1,447 yards.

If Texas wants to win this game their defense is going to have to continue to play well.  Texas’s defense has been very good this season and is holding opponents to 289 yards of offense and only 14.7 points-per-game.

Oklahoma is the better team in this game but I like Texas to hang around and make this a close game. I am going to take Texas with the points.  Oklahoma-Texas spread pick: Texas +9.5

#17 Florida v #1 LSU

  • Florida-LSU spread: LSU-14
  • Florida-LSU over/under 41.5

Florida heads to Death Valley to face LSU and have to do it with a freshman quarterback making his first start.  Florida lost their starting quarterback John Brantley against Alabama and now must to turn to Jeff Driskel to prevent them from getting their second loss of the season.  Against Alabama, Driskel went 2-6 for 14 yards and must get better in a hurry for them to have a chance in this game.

By now everyone knows about the LSU defense which has the potential to carry them to a national championship.  The Tigers secondary is not going to get beat in this game with the pass and the defensive line must step up in this game.  Florida has two very talented running backs and if LSU can stop them than this game won’t even close.

I like LSU to win this game but I think Florida will play better than they did last week and that is why I am going to take Florida with the points. Florida-LSU spread pick: Florida +14

Iowa v Penn State

  • Iowa-Penn State spread: Penn State -4
  • Iowa-Penn State over/under 44.5

The Hawkeye’s have owned Penn State and have won eight out of the last nine meetings.  The Hawkeyes have one of the best offenses in the Big Ten this season and are led by quarterback James Vandenberg. Vandenberg has been a pleasant surprise for the Hawkeyes this season and has thrown 10 touchdown passes and only one interception.  The Hawkeyes have the best set of receivers in the Big Ten and have been tough for opposing teams to stop.

Penn State has one of the best defenses in the country and is holding teams to only 12 points-per-game.  The problem this season for the Nittany Lions is their offense as they have been absolutely awful at times.  Rob McGloin has thrown for over 200 yards in each of the last two games and has played very well.  As well as McGloin has played, the Nittany Lions still use a two quarterback system and Rob Bolden has thrown an interception four games in a row.

Iowa is going to put a lot of points on the board and Penn State is going to have a hard time keeping up in this one.  I like Iowa to win this game straight up. Iowa-Penn State spread pick: Iowa +4


And now for the fun, free suggestion.

The guys at Daily Joust, who run one of the best weekly fantasy sports platforms on the web, have partnered with MSF to host a free college football fantasy challenge for this week. The best part is that while it’s free to enter, there are $250 real dollars on the line.

This week’s challenge is Big 10-specific. Read the details and get started by clicking here.  If you’re not a Big 10 fan and would rather play in one of the other conference-specific challenges or just a general college football fantasy challenge for this week, then click here.

I’ll be playing in the Big 10 challenge, as will Tyler, Keith, and Jerod from MSF. Hope to see you there!


* – Texas Oklahoma photo credit: via News Ok

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