Teddy Bridgestone threw for one touchdown, Andrew Johnson returned a blocked field goal for another score and Louisville shocked No. 24 West Virginia 38-35 Saturday.
Not expected to be a factor in the Big East this season, the surprising Cardinals (5-4, 3-1) won their third straight in a tight race and dealt a severe blow to West Virginia's title chances.
Louisville also got a payback of sorts after being overlooked in the recent Big 12 expansion sweepstakes, a bid that went to the Mountaineers.
Three different backs scored rushing touchdowns for Louisville, which broke a four-game losing streak in the series.
Geno Smith threw for 410 yards and three scores but couldn't bring the Mountaineers (6-3, 2-2) back from 10 points down in the fourth quarter.