Marcus Mariota threw for a career-high 456 yards and four touchdowns and No. 2 Oregon handed Tennessee its first loss of the season, 59-14 on Saturday.
Freshman Johnny Mundt, who replaced ailing tight end Colt Lyerla, had five catches for 121 yards and two TDs for the Ducks (3-0). Josh Huff added six catches for 125 yards and a score.
Mariota, who completed 23 of 33 passes, was the first Oregon quarterback to throw for more than 400 yards in a game since Kellen Clemens in 2005. The sophomore quarterback's yardage ties for the third-most in a game in school history.
Oregon's sloppy play at the start - four penalties for 35 yards in the first quarter - helped Tennessee (2-1) take an early lead, but it was fleeting and the Ducks led 38-7 at halftime.
Justin Worley completed 13 of 25 passes for 127 yards and a touchdown for the Volunteers, who opened the season with easy home wins over Austin Peay and Western Kentucky. But Tennessee could not keep up with the speedy Ducks, who had 6...