Purdue pushed Michigan onto its heels, marching down the field on the opening drive that was capped by Caleb TerBush's short pass that Gary Bush turned into a long touchdown that quieted the Big House.
Then, the Boilermakers didn't do much other than continue their pattern of alternating winning and losing.
Fitzgerald Toussaint ran for a career-high 170 yards and two TDs to lead the 17th-ranked Wolverines to a 36-14 win over Purdue on Saturday.
''I loved the way we started with that first drive and we never got that going again,'' Boilermakers receiver Justin Siller said. ''I don't understand it.''
Purdue (4-4, 2-2 Big Ten) hasn't won or lost consecutive games this year, but is still two victories from being bowl eligible for the first time since 2007.
Michigan (7-1, 3-1 Big Ten) scored 36 straight points after falling behind early and bounced back from their first loss of the season two weeks ago at Michigan State.