Shawne Alston rushed for two second-half touchdowns, including a 1-yarder with 6:10 left, and West Virginia came from 10 points down to beat Pittsburgh 21-20 on Friday night.
West Virginia sacked Tino Sunseri 10 times, including four on Pittsburgh's final drive, when time ran out on the Panthers.
The Mountaineers (8-3, 4-2 Big East) can earn a share of the conference title next week at South Florida. West Virginia also hold slim hopes for earning the league's automatic BCS berth and would need some help in a tight league race.
Pittsburgh (5-6, 3-3) led 17-7 at halftime but was limited to 80 yards in the second half.
Pittsburgh starting running back Zach Brown left the game with an undisclosed injury just before halftime and backup Isaac Bennett left the game midway through the third. Bennett would later return, but Pittsburgh's offense stalled and West Virginia gained momentum.
Alston's 8-yard TD run midway through the third quarter cut West Virginia's deficit to 20-14.