Mississippi defensive end Wayne Dorsey and cornerback Marcus Temple are out for the season after getting injured in Saturday's 52-7 loss to No. 2 Alabama.
It's more bad news for the Rebels, who have lost 11 of their past 12 Southeastern Conference games dating back to 2009.
Both seniors were key contributors on defense. Dorsey is leading Ole Miss with five tackles for a loss and three sacks while Temple has 28 tackles and is second on the team with two interceptions.
Ole Miss coach Houston Nutt said the two were ''good captains who have done a lot for us.'' Nutt said both players had surgery on Sunday morning in Jackson, Miss.
Ole Miss hosts No. 10 Arkansas on Saturday at Vaught-Hemingway Stadium.