Ron Brooks returned an interception for a touchdown 28 seconds into the game and top-ranked LSU never looked back, piling up 353 yards rushing on the way to a 52-3 rout of Mississippi on Saturday night.
The Tigers (11-0, 7-0 Southeastern Conference), who matched their best start since 1958, built a 35-3 halftime lead.
Quarterback Jordan Jefferson started his second consecutive game, completing 7 of 7 passes for 88 yards and a touchdown. Alfred Blue led the Tigers with 74 rushing yards while Spencer Ware added 70 yards and a touchdown.
Ole Miss (2-9, 0-7) has lost six straight games and a school-record 13 straight conference games. Barry Brunetti rushed for a team-high 74 yards as the Rebels managed just 195 total yards.